Accuracy of Diagnostic Tests for the Detection of Chagas Disease: A Systematic Review and Meta-Analysis

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dc.creatorMayron Antonio Candia-puma
dc.creatorLaura Yesenia Machaca-luque
dc.creatorBrychs Milagros Roque-pumahuanca
dc.creatorAlexsandro Sobreira Galdino
dc.creatorRodolfo Cordeiro Giunchetti
dc.creatorEduardo Antonio Ferraz Coelho
dc.creatorMiguel Angel Chávez Fumagalli
dc.date.accessioned2023-11-06T20:47:53Z
dc.date.accessioned2025-09-09T01:26:48Z
dc.date.available2023-11-06T20:47:53Z
dc.date.issued2022-11-10
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/diagnostics12112752
dc.identifier.issn2075-4418
dc.identifier.urihttps://hdl.handle.net/1843/60529
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofDiagnostics
dc.rightsAcesso Aberto
dc.subjectImunologia
dc.subjectMedicina
dc.subjectSensibilidade e Especificidade
dc.subjectRevisão Sistemática
dc.subjectMetanálise
dc.subjectDoença de Chagas
dc.subjectTestes Diagnósticos de Rotina
dc.subject.otherDiagnostic tests
dc.subject.otherChagas disease
dc.subject.otherMeta-analysis
dc.subject.otherSystematic review
dc.subject.otherSensitivity
dc.subject.otherSpecificity
dc.titleAccuracy of Diagnostic Tests for the Detection of Chagas Disease: A Systematic Review and Meta-Analysis
dc.typeArtigo de periódico
local.citation.epage20
local.citation.issue11
local.citation.spage2752
local.citation.volume12
local.description.resumoThe present systematic review and meta-analysis about the accuracy of diagnostic tests aim to describe the findings of literature over the last thirty years for the diagnosis of Chagas disease (CD). This work aimed to determine the accuracy of diagnostic techniques for CD in the disease’s acute and chronic phases. The PubMed database was searched for studies published between 1990 and 2021 on CD diagnostics. Fifty-six published studies that met the criteria were analyzed and included in the meta-analysis, evaluating diagnostic accuracy through sensitivity and specificity. For Enzyme-Linked Immunosorbent Assay (ELISA), Fluorescent Antibody Technique (IFAT), Hemagglutination Test (HmT), Polymerase Chain Reaction (PCR), and Real-Time Polymerase Chain Reaction (qPCR) diagnosis methods, the sensitivity had a median of 99.0%, 78.0%, 75.0%, 76.0%, and 94.0%, respectively; while specificity presented a median of 99.0%, 99.0%, 99.0%, 98.0%, and 98.0%, respectively. This meta-analysis showed that ELISA and qPCR techniques had a higher performance compared to other methods of diagnosing CD in the chronic and acute phases, respectively. It was concluded utilizing the Area Under the Curve restricted to the false positive rates (AUCFPR), that the ELISA diagnostic test presents the highest performance in diagnosing acute and chronic CD, compared to serological and molecular tests. Future studies focusing on new CD diagnostics approaches should be targeted.
local.identifier.orcidhttps://orcid.org/0000-0002-6328-3840
local.identifier.orcidhttps://orcid.org/0000-0002-8890-3030
local.identifier.orcidhttps://orcid.org/0000-0003-4181-7546
local.identifier.orcidhttps://orcid.org/0000-0002-6681-9014
local.identifier.orcidhttps://orcid.org/0000-0002-8394-4802
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2075-4418/12/11/2752

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