Pathological fracture after radiotherapy: systematic review of literature

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dc.creatorCláudio Beling Gonçalvessoares
dc.creatorIvana Duval de Araújo
dc.creatorBruno Jannotti Pádua
dc.creatorJosé Carlos Souza Vilela
dc.creatorRodrigo Henriques Reis Souza
dc.creatorLuiz Eduardo Moreira Teixeira
dc.date.accessioned2023-05-22T19:56:21Z
dc.date.accessioned2025-09-09T01:19:35Z
dc.date.available2023-05-22T19:56:21Z
dc.date.issued2019-09-02
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1806-9282.65.6.902
dc.identifier.issn01044230
dc.identifier.urihttps://hdl.handle.net/1843/53761
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.rightsAcesso Aberto
dc.subjectFraturas Espontâneas
dc.subjectConsolidação da Fratura
dc.subjectRadioterapia
dc.subjectEfeitos da Radiação
dc.subject.otherFractures, Spontaneous
dc.subject.otherFracture Healing
dc.subject.otherRadiotherapy
dc.subject.otherRadiation Effects
dc.titlePathological fracture after radiotherapy: systematic review of literature
dc.typeArtigo de periódico
local.citation.epage908
local.citation.issue6
local.citation.spage902
local.citation.volume65
local.description.resumoOBJECTIVE: To evaluate the epidemiological data and available treatments for fractures secondary to radiotherapy treatment. METHODS: Identification of publications on pathological skeletal fractures previously exposed to ionizing radiation. RESULTS: The incidence of fractures after irradiation varies from 1.2% to 25% with a consolidation rate of 33% to 75%, being more frequent in the ribs, pelvis, and femur. The time elapsed between irradiation and fracture occurs years after radiotherapy. Risk factors include age above 50 years, female gender, extensive periosteal detachment, circumferential irradiation, tumor size, and anterior thigh location. The etiology is still uncertain, but cellular disappearance, reduction of bone turnover and activity were observed hematopoietic as possible causes of failure of consolidation.CONCLUSION: There is no consensus in the literature on the factors related to the development of fractures, with radiation dose, previous tumor size and periosteal detachment being suggested as potential factors.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/ramb/a/VcgCJ7W9bPrg5SgPT5QcQ6m/?lang=en

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