Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month randomized controlled clinical trial

Página do item simplificado
dc.creatorBernardo de Carvalho Dutra
dc.creatorAlcione Maria Soares Dutra Oliveira
dc.creatorPeterson Antônio Dutra Oliveira
dc.creatorLuís Otávio de Miranda Cota
dc.creatorJuliana Oliveira Silveira
dc.creatorFernando de Oliveira Costa
dc.date.accessioned2024-04-30T18:52:42Z
dc.date.accessioned2025-09-08T23:56:42Z
dc.date.available2024-04-30T18:52:42Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1002/JPER.19-0160
dc.identifier.issn1943-3670
dc.identifier.urihttps://hdl.handle.net/1843/68003
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Periodontology
dc.rightsAcesso Restrito
dc.subjectAlendronate
dc.subjectBone regeneration
dc.subjectRadiography, dental, digital
dc.subjectPeriodontitis
dc.subjectOral surgical procedures
dc.subjectBone and bones
dc.subject.otheralendronate sodium randomized clinical trials
dc.subject.otherperiodontal surgical
dc.subject.otheracesso restrito busca dia 23/04/2024 fao clínica assunto:Alendronate periódico: Journal of periodontology Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month randomized controlled clinical trial
dc.subject.otherKeywords: alendronate; bone regeneration; dental digital radiography; periodontitis.
dc.titleEffects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: a 6-month randomized controlled clinical trial
dc.typeArtigo de periódico
local.description.resumoBackground Sodium alendronate (ALN) is an aminobisphosphonate and potent inhibitor of bone resorption. It has been suggested that ALN might be a promising carrier of biomolecules for periodontal bone repair. The aim of this randomized split-mouth clinical trial was to evaluate the effects of the topical application of 1% ALN gel in intrabony defects during the surgical treatment of patients with periodontitis. Methods Sixty-four intrabony defects from 32 patients with periodontitis were randomly treated with either 1% ALN gel or placebo gel during periodontal surgeries. Full-mouth periodontal examination was performed at baseline and at 3 and 6 months after surgical treatment. Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were recorded as the clinical outcomes. Bone defects were evaluated by digital subtraction radiography (DSR) at baseline and 6 months post-treatment. Analyses were performed through Fisher, Kruskal-Wallis, and ANOVA tests and a generalized estimation equations method. Results Both ALN and placebo groups showed significant improvements in BOP, PD, and CAL after periodontal surgical procedures (P < 0.001). Intergroup analysis showed significantly better outcomes in the ALN group with higher PD reduction and clinical attachment gain. DSR showed positive effects on periodontal bone repair strongly associated in the ALN group (P < 0.001). Conclusion Topical application of 1% ALN may be a promising and beneficial adjuvant for the treatment of intrabony defects during surgical periodontal therapy.
local.identifier.orcids
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://aap.onlinelibrary.wiley.com/doi/10.1002/JPER.19-0160

Arquivos

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG