Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma

Página do item simplificado
dc.creatorEliane Macedo Sobrinho Santos
dc.creatorTalita Antunes Guimarães
dc.creatorHércules Otacílio Santos
dc.creatorLilian Mendes Borborema Cangussu
dc.creatorSabrina Ferreira de Jesus
dc.creatorCarlos Alberto de Carvalho Fraga
dc.creatorCláudio Marcelo Cardoso
dc.creatorSérgio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorRicardo Santiago Gomez
dc.creatorAndré Luiz Sena Guimarães
dc.creatorLucyana Conceição Farias
dc.date.accessioned2023-12-04T13:15:29Z
dc.date.accessioned2025-09-09T00:00:19Z
dc.date.available2023-12-04T13:15:29Z
dc.date.issued2017-05-01
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1177/101042831769913
dc.identifier.issn1423-0380
dc.identifier.urihttps://hdl.handle.net/1843/61670
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTumor Biology
dc.rightsAcesso Aberto
dc.subjectCarcinoma de células escamosas
dc.subjectApoptose
dc.subjectCabeça - Câncer
dc.subjectPescoço - Câncer
dc.subjectBoca - Câncer
dc.subjectNeovascularização
dc.subject.othercarcinoma de células escamosas de boca
dc.subject.othercâncer de cabeça e pescoço
dc.subject.otherBIOLOGIA MOLECULAR
dc.subject.otherPATOGENIA
dc.titleLeptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage11
local.citation.spage1
local.description.resumoLeptin, one of the main hormones controlling energy homeostasis, has been associated with different cancer types. In oral cancer, its effect is not well understood. We investigated, through in vitro and in vivo assays, whether leptin can affect the neoplastic behavior of oral squamous cell carcinoma. Expression of genes possibly linked to the leptin pathway was assessed in leptin-treated oral squamous cell carcinoma cells and also in tissue samples of oral squamous cell carcinoma and oral mucosa, including leptin, leptin receptor, hypoxia-inducible factor 1-alpha, E-cadherin, matrix metalloproteinase-2, matrix metalloproteinase-9, Col1A1, Ki67, and mir-210. Leptin treatment favored higher rates of cell proliferation and migration, and reduced apoptosis. Accordingly, leptin-treated oral squamous cell carcinoma cells show decreased messenger RNA caspase-3 expression, and increased levels of E-cadherin, Col1A1, matrix metalloproteinase-2, matrix metalloproteinase-9, and mir-210. In tissue samples, hypoxia-inducible factor 1-alpha messenger RNA and protein expression of leptin and leptin receptor were high in oral squamous cell carcinoma cases. Serum leptin levels were increased in first clinical stages of the disease. In animal model, oral squamous cell carcinoma–induced mice show higher leptin receptor expression, and serum leptin level was increased in dysplasia group. Our findings suggest that leptin seems to exert an effect on oral squamous cell carcinoma cells behavior and also on molecular markers related to cell proliferation, migration, and tumor angiogenesis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://journals.sagepub.com/doi/10.1177/1010428317699130

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Leptin acts on neoplastic behavior and expression levels of genes related to hypoxia, angiogenesis, and invasiveness in oral squamous cell carcinoma.pdf
Tamanho:
1.33 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG