Celecoxib modulates renin-angiotensin system in the adipose tissue of obese mice

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dc.creatorJamille Fernandes Lula
dc.creatorToni Ramos Alves de Souza
dc.creatorKeila Lopes Mendes
dc.creatorAlanna Fernandes Paraíso
dc.creatorDeborah de Farias Lelis
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorLucyana Conceição de Farias
dc.creatorIgor Viana Brandi
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAline Hilzenderguer
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-22T15:33:07Z
dc.date.accessioned2025-09-09T00:07:45Z
dc.date.available2022-08-22T15:33:07Z
dc.date.issued2018
dc.identifier.doi10.2174/1573408014666180705145324
dc.identifier.issn1875-6662
dc.identifier.urihttps://hdl.handle.net/1843/44449
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Enzyme Inhibition
dc.rightsAcesso Aberto
dc.subjectObesidade
dc.subjectSistema renina-angiotensina
dc.subjectAnalgésicos
dc.subjectAgentes antiinflamatórios não esteróides
dc.titleCelecoxib modulates renin-angiotensin system in the adipose tissue of obese mice
dc.typeArtigo de periódico
local.citation.epage209
local.citation.issue3
local.citation.spage203
local.citation.volume14
local.description.resumoBackground: the renin-angiotensin system (RAS) is a critical contributing factor to obesity and related diseases. Several studies have shown the relationship of obesity with cyclooxygenase-2. Objectives: based on these facts, we aimed to investigate the celecoxib oral administration (a selective anti-inflammatory inhibitor of cyclooxygenase-2 (ICOX-2)) effects, in mice fed a high-fat diet by assessing the renin-angiotensin system and inflammatory markers expression. Methods: FVB/N male mice were divided into 3 groups and fed with experimental diets, standard, high-fat diet and high-fat diet plus ICOX-2 at a dose of 100mg/kg/body weight. Body weight, food intake, blood parameters and RAS/inflammatory markers expression were assessed. Results: the main findings showed that diet-induced obese mice treated with COX-2 inhibitor showed significantly improved glucose and insulin homeostasis, presented decreased body weight gain and the biochemical analyses revealed reduced triglyceride levels and higher serum HDL-c levels as compared to HFD and ST. These results were accompanied by a downregulation of AGT, ACE, TNF-α and IL-6 expression in the group receiving treatment. Conclusion: taken together, these results indicate that ICOX-2 may exhibit therapeutic potential for obesity via the renin-angiotensin system and inflammation.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttp://www.eurekaselect.com/article/91529

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