Association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis patients using fixed-dose combination therapy in Contagem, Minas Gerais, Brazil

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dc.creatorAna Maria Viegas
dc.creatorSilvana Spíndola de Miranda
dc.creatorJoão Paulo Haddad
dc.creatorMaria das Graças Braga Ceccato
dc.creatorWânia da Silva Carvalho
dc.date.accessioned2025-04-16T20:50:52Z
dc.date.accessioned2025-09-08T23:32:35Z
dc.date.available2025-04-16T20:50:52Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/S1678-9946201759028
dc.identifier.issn1678-9946
dc.identifier.urihttps://hdl.handle.net/1843/81675
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista do instituto de medicina tropical de São Paulo
dc.rightsAcesso Aberto
dc.subjectTuberculose
dc.subjectTerapia combinada
dc.subjectCooperação do paciente
dc.subjectAdesão à medicação
dc.subjectCooperação e adesão ao tratamento
dc.subject.otherTuberculosis
dc.subject.otherAntibacterials
dc.subject.otherComprehension
dc.titleAssociation of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis patients using fixed-dose combination therapy in Contagem, Minas Gerais, Brazil
dc.typeArtigo de periódico
local.citation.epage6
local.citation.spage1
local.citation.volume59
local.description.resumoThe present study aimed to assess the association of outcomes with comprehension, adherence and behavioral characteristics of tuberculosis (TB) patients using fixed-dose combination (FDC) therapy in the city of Contagem, MG, Brazil. This study used standardized questionnaires to collect data. Outcomes included cure in 77.2% (64/ 83), noncompliance with treatment in 20.4% (17/ 83), and absence of organ failure or death cases. The rate of adherence to treatment was high (71.1% - 59/ 83), while the level of comprehension of the treatment was insufficient for the majority of patients (72.3% - 60/ 83). When a greater number of medicines was used, the chance of noncompliance with treatment increased exponentially (p = 0.00 - OR 1.72). Light-skinned black patients, alcoholics and those who live with HIV/ AIDS showed a significant association with noncompliance with treatment (p=0.039 - OR 3.38, p=0.002 - OR 4.68, and p=0.001 - OR 9.68, respectively). Comprehension also presented a significant association with noncompliance with treatment (p=0.01 and OR 5.76 and CI 1.49-22.29). The probability of noncompliance with treatment in the first few months was greater than in the subsequent months. This study demonstrates that if the TB patients had a better understanding of the treatment, the outcome would have been more favorable as regards a proper cure.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE FARMÁCIA SOCIAL
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/rimtsp/a/mHwF6GsJMDszMqGPFbcq7TM/?lang=en

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