Sintomas da Síndrome Pós-ressecção Anterior do Reto (LARS) em população não operada: estudo observacional multicêntrico

Abstract

Rectal cancer is an oncological disease of worldwide relevance. Its standard treatment is rectal anterior resection with or without chemoradiotherapy. However, there is an increase in intestinal dysfunctions associated with its oncological treatment with a great impact on quality of life known as low anterior resection syndrome (LARS). One of its main limitations is the lack of baseline data from the general population for comparison. Our objective was to evaluate the low anterior resection syndrome score in a baseline population who did not undergo colorectal surgery and didn't have colorectal cancer. LARS score was applied in patients who underwent surveillance colonoscopy between 2021 and 2022. After sample calculation, 215 patients were included, of which 8.9% scored as Major LARS and 18.1% Minor LARS. In multivariate analysis, diabetes was a predictive factor for Major LARS score, increasing its odds by 4.5 times. Therefore, evacuation disorders compatible with low anterior resection syndrome in the general population should have their impact taken into account in the analysis of the incidence of LARS in patients in the postoperative period of anterior rectal resection.