Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes

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dc.creatorMikelly Santos Coutinho-da-Silva
dc.creatorLis Ribeiro do Valle Antonelli
dc.creatorVitor Bortolo de Rezende
dc.creatorFernanda Ludolf Ribeiro de Melo
dc.creatorCristiana Couto Garcia
dc.creatorJesuanne Carla Silva-Andrade
dc.creatorIsmael Artur da Costa-Rocha
dc.creatorMichele de Souza Bastos
dc.creatorLucia Alves da Rocha
dc.creatorValderjane Aprigio Silva
dc.creatorEwerton da Silva Ferreira
dc.creatorPedro Henrique Ferreira Sucupira
dc.creatorEveny Perlize Melo Marinho
dc.creatorAllyson Guimarães Costa
dc.creatorMatheus de Souza Gomes
dc.creatorLaurence Rodrigues Amaral
dc.creatorErilene Cristina da Silva Furtado
dc.creatorEliana Vieira Pinto da Silva
dc.creatorBruna Alves Ramos
dc.creatorÉder Barros Dos Santos
dc.creatorMaria Nazaré Oliveira Freitas
dc.creatorPedro Fernando da Costa Vasconcelos
dc.creatorKelly Alves Bicalho
dc.creatorOlindo Assis Martins-Filho
dc.creatorMárcio Sobreira Silva Araújo
dc.creatorMilene Silveira Ferreira
dc.creatorLivia Carício Martins
dc.creatorAna Carolina Campi-Azevedo
dc.creatorJoaquim Pedro Brito-de-Sousa
dc.creatorVanessa Peruhype-Magalhães
dc.creatorMaria Rios
dc.creatorAndrea Teixeira-Carvalho
dc.creatorJordana Grazziela Alves Coelho Dos Reis
dc.date.accessioned2023-11-28T20:31:05Z
dc.date.accessioned2025-09-09T00:53:24Z
dc.date.available2023-11-28T20:31:05Z
dc.date.issued2022-05-31
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3389/fimmu.2022.892990
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/1843/61471
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofFrontiers in Immunology
dc.rightsAcesso Aberto
dc.subjectCitocinas
dc.subjectQuimiocinas
dc.subjectSorogrupo
dc.subjectImunidade
dc.subjectDengue
dc.subject.otherDengue infection
dc.subject.otherDengue virus
dc.subject.otherImmune response
dc.subject.otherDENV serotypes
dc.subject.otherChemokines
dc.subject.otherCytokines
dc.titleSerum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes
dc.typeArtigo de periódico
local.citation.epage12
local.citation.spage892990
local.citation.volume13
local.description.resumoA panoramic analysis of chemokines, pro-inflammatory/regulatory cytokines, and growth factors was performed in serum samples from patients with acute DENV infection (n=317) by a high-throughput microbeads array. Most soluble mediators analyzed were increased in DENV patients regardless of the DENV serotype. The substantial increase (≥10-fold) of CXCL10, IL-6, and IFN-γ, and decreased levels of PDGF (<0.4-fold) was universally identified in all DENV serotypes. Of note, increased levels of CXCL8, CCL4, and IL-12 (≥3-9-fold) were selectively observed in DENV2 as compared to DENV1 and DENV4. Heatmap and biomarker signatures further illustrated the massive release of soluble mediators observed in DENV patients, confirming the marked increase of several soluble mediators in DENV2. Integrative correlation matrices and networks showed that DENV infection exhibited higher connectivity among soluble mediators. Of note, DENV2 displayed a more complex network, with higher connectivity involving a higher number of soluble mediators. The timeline kinetics (Day 0-1, D2, D3, D4-6) analysis additionally demonstrated differences among DENV serotypes. While DENV1 triggers a progressive increase of soluble mediators towards D3 and with a decline at D4-6, DENV2 and DENV4 develop with a progressive increase towards D4-6 with an early plateau observed in DENV4. Overall, our results provided a comprehensive overview of the immune response elicited by DENV infection, revealing that infection with distinct DENV serotypes causes distinct profiles, rhythms, and dynamic network connectivity of soluble mediators. Altogether, these findings may provide novel insights to understand the pathogenesis of acute infection with distinct DENV serotypes.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://www.frontiersin.org/articles/10.3389/fimmu.2022.892990/full

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