Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions

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dc.creatorTalita Antunes Guimarães
dc.creatorLucyana Conceição Farias
dc.creatorCarlos Alberto de Carvalho Fraga
dc.creatorJohn David Feltenberger
dc.creatorGeraldo Aclécio Melo
dc.creatorRicardo Della Coletta
dc.creatorSergio Henrique Sousa Santos
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.date.accessioned2022-08-16T11:30:21Z
dc.date.accessioned2025-09-09T01:33:28Z
dc.date.available2022-08-16T11:30:21Z
dc.date.issued2016-06
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.1097/CAD.0000000000000342
dc.identifier.issn1473-5741
dc.identifier.urihttps://hdl.handle.net/1843/44259
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAnti-Cancer Drugs
dc.rightsAcesso Aberto
dc.subjectBoca - Câncer
dc.subjectApoptose
dc.subjectÁcido gálico
dc.subjectBioinformática
dc.subjectCélulas - Proliferação
dc.subjectTumores
dc.titleEvaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions
dc.typeArtigo de periódico
local.citation.epage416
local.citation.issue5
local.citation.spage407
local.citation.volume27
local.description.resumoThe purpose of the current study was to develop and test a theoretical model that could explain the mechanism of action of gallic acid (GA) in the oral squamous cell carcinoma context for the first time. The theoretical model was developed using bioinformatics and interaction network analysis to evaluate the effect of GA on oral squamous cell carcinoma. In a second step to confirm theoretical results, migration, invasion, proliferation, and gene expression (Col1A1, E-cadherin, HIF-1α, and caspase-3) were performed under normoxic and hypoxic conditions. Our study indicated that treatment with GA resulted in the inhibition of cell proliferation, migration, and invasion in neoplastic cells. Observation of the molecular mechanism showed that GA upregulates E-cadherin expression and downregulates Col1A1 and HIF-1α expression, suggesting that GA might be a potential anticancer compound. In conclusion, the present study demonstrated that GA significantly reduces cell proliferation, invasion, and migration by increasing E-cadherin and repressing Col1A1.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://journals.lww.com/anti-cancerdrugs/Fulltext/2016/06000/Evaluation_of_the_antineoplastic_activity_of.4.aspx

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