Oral angiotensin-(1-7) peptide modulates intestinal microbiota improving metabolic profile in obese mice

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dc.creatorAmanda Souto Machado
dc.creatorCláudia Regina Vieira
dc.creatorUlisses Alves Pereira
dc.creatorTheles de Oliveira Costa
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorRobson a s Dos Santos
dc.creatorSergio Henrique Sousa Santos
dc.creatorJanaína Ribeiro Oliveira
dc.creatorDeborah Farias Lelis
dc.creatorVictor Hugo Dantas Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorAndré Luiz Sena Guimarães
dc.creatorIgor Viana Brandi
dc.creatorBruna Mara Aparecida de Carvalho Mesquita
dc.creatorDiego Vicente da Costa
dc.date.accessioned2023-03-30T14:47:22Z
dc.date.accessioned2025-09-09T01:16:19Z
dc.date.available2023-03-30T14:47:22Z
dc.date.issued2021
dc.identifier.doihttp://dx.doi.org/10.2174/0929866528666210816115645
dc.identifier.issn1875-5305
dc.identifier.urihttps://hdl.handle.net/1843/51369
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProtein and peptide letters
dc.rightsAcesso Restrito
dc.subjectIntestinos -- Microbiologia
dc.subjectEndotoxina
dc.subjectMetabolismo
dc.subjectSistema renina-angiotensina
dc.subjectIntestino delgado
dc.titleOral angiotensin-(1-7) peptide modulates intestinal microbiota improving metabolic profile in obese mice
dc.typeArtigo de periódico
local.citation.epage1137
local.citation.issue10
local.citation.spage1127
local.citation.volume28
local.description.resumoBackground: Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota. Objective: The present study aimed to evaluate the Angiotensin-(1-7) [ANG-(1-7)] oral formulation effects on obese mice intestinal microbiota. Methods: Mice were divided into four groups: obese and non-obese treated with ANG-(1-7) and obese and non-obese without ANG-(1-7) during four weeks. Results: We observed a significant decrease in the fasting plasma glucose, total cholesterol, triglycerides, and Low-density lipoprotein levels and increased High-density lipoprotein in animals treated with ANG-(1-7). The histological analysis showed intestinal villi height reduction in mice treated with ANG-(1-7). Additionally, increased Bacteroidetes and decreased Firmicutes (increased Bacteroidetes/ Firmicutes ratio) and Enterobacter cloacae populations were observed in the High-Fat Diet + ANG-(1-7) group. Receptor toll-like 4 (TLR4) intestinal mRNA expression was reduced in the HFD+ANG-(1-7) group. Finally, the intestinal expression of the neutral amino acid transporter (B0AT1) was increased in animals treated with ANG-(1-7), indicating a possible mechanism associated with tryptophan uptake. Conclusion: The results of the present study suggest for the first time an interaction between oral ANG-(1-7) and intestinal microbiota modulation.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/117376i

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