Versatile grafted microcrystalline cellulose with ionic liquid as new Losartan-controlled release material

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dc.creatorStefânia Sales de Oliveira Santos
dc.creatorRubén Dario Sinisterra Millán
dc.creatorMarcelo Gomes Speziali
dc.date.accessioned2024-01-26T17:58:21Z
dc.date.accessioned2025-09-09T00:24:21Z
dc.date.available2024-01-26T17:58:21Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1016/j.eurpolymj.2020.109490
dc.identifier.issn0014-3057
dc.identifier.urihttps://hdl.handle.net/1843/63431
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Polymer Journal
dc.rightsAcesso Restrito
dc.subjectQuímica
dc.subjectTecnologia de liberação controlada
dc.subjectAgentes hipotensores
dc.subjectCinética quimica
dc.subjectQuímica de superfície
dc.subjectCelulose - Química
dc.subject.otherpH-dependent
dc.subject.otherSilanization
dc.subject.otherLosartan
dc.subject.otherDesorption
dc.subject.otherKorsmeyer – Peppas kinetic model
dc.subject.otherWeibull kinetic model
dc.titleVersatile grafted microcrystalline cellulose with ionic liquid as new Losartan-controlled release material
dc.typeArtigo de periódico
local.citation.volume124
local.description.resumoThis paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems.
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0003-3572-9670
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0014305719320543

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