pH-sensitive, long-circulating liposomes as an alternative tool to deliver doxorubicin into tumors: a feasibility animal study

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dc.creatorJuliana de Oliveira Silva
dc.creatorRenata Salgado Fernandes
dc.creatorSávia Caldeira de Araújo Lopes
dc.creatorValbert Nascimento Cardoso
dc.creatorElaine Amaral Leite
dc.creatorGeovanni Dantas Cassali
dc.creatorMaria Cristina Marzola
dc.creatorDomenico Rubello
dc.creatorMônica Cristina de Oliveira
dc.creatorAndré Luís Branco de Barros
dc.date.accessioned2022-03-15T16:02:22Z
dc.date.accessioned2025-09-08T23:06:33Z
dc.date.available2022-03-15T16:02:22Z
dc.date.issued2016-12
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1007/s11307-016-0964-7
dc.identifier.issn1860-2002
dc.identifier.urihttps://hdl.handle.net/1843/40099
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMolecular Imaging and Biology
dc.rightsAcesso Restrito
dc.subjectLipossomos
dc.subjectDoxorrubicina
dc.subjectNeoplasias
dc.subjectCâncer
dc.subjectTecnécio
dc.subject.otherpH-sensitive liposome
dc.subject.otherLong circulating
dc.subject.otherDoxorubicin
dc.subject.otherTumor
dc.subject.otherCancer
dc.subject.other4T1 murine model
dc.titlepH-sensitive, long-circulating liposomes as an alternative tool to deliver doxorubicin into tumors: a feasibility animal study
dc.typeArtigo de periódico
local.citation.epage904
local.citation.issue6
local.citation.spage898
local.citation.volume18
local.description.resumoPurpose: Therapeutic agents used in chemotherapy have low specificity leading to undesired severe side effects. Hence, the development of drug delivery systems that improve drug specificity, such as liposome moieties, is an alternative to overcome chemotherapy limitations and increase antitumor efficacy. In this study, the biodistribution profile evaluation of pH-sensitive long-circulating liposomes (SpHL) containing [99mTc]DOX in 4T1 tumor-bearing BALB/c mice is described. Procedures: [99mTc]DOX was radiolabeled by direct method. Liposomes were prepared and characterized. [99mTc]DOX was encapsulated into liposomes by freezing and thawing. Circulation time for SpHL-[99mTc]DOX was determined by measuring the blood activity from healthy animals. Biodistribution studies were carried out in tumor-bearing mice at 1, 4, and 24 h after injection. Results: Blood levels of the SpHL-[99mTc]DOX declined in a biphasic manner, with an α half-life of 14.1 min and β half-life of 129.0 min. High uptake was achieved in the liver and spleen, due to the macrophages captured. Moreover, tumor uptake was higher than control tissue, resulting in high tumor-to-muscle ratios, indicating higher specificity for the tumor area. Conclusion: [99mTc]DOX was successfully encapsulated in liposomes. Biodistribution indicated high tumor-to-muscle ratios in breast tumor-bearing BALB/c mice. In summary, these results showed the higher accumulation of SpHL-[99mTc]DOX in the tumor area, suggesting selective delivery of doxorubicin into tumor.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11307-016-0964-7

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