Chemical, microscopic, and microbiological analysis of a functionalizedpoly-ether-ether-ketone-embedding antibiofilm compounds

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dc.creatorJuan Felipe Dumes Montero
dc.creatorLuiz Cláudio de Almeida Barbosa
dc.creatorUlisses Alves Pereira
dc.creatorGuilherme Mariz de Oliveira Barra
dc.creatorMarcio Celso Fredel
dc.creatorCesar Augusto Magalhães Benfatti
dc.creatorRicardo de Souza Magini
dc.creatorAndréa de Lima Pimenta
dc.creatorJúlio César Matias de Souza
dc.date.accessioned2022-09-23T13:53:50Z
dc.date.accessioned2025-09-08T23:35:11Z
dc.date.available2022-09-23T13:53:50Z
dc.date.issued2016-07-26
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1002/jbm.a.35842
dc.identifier.issn1552-4965
dc.identifier.urihttps://hdl.handle.net/1843/45416
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Biomedical Materials Research Part A
dc.rightsAcesso Restrito
dc.subjectStreptococcus mutans
dc.subjectBiofilme
dc.subjectImplantes ortopédicos
dc.subjectEspectroscopia de infravermelho
dc.subjectLactamas
dc.subjectMateriais biomédicos
dc.subject.otherPEEK
dc.subject.otherlactams
dc.subject.otherStreptococcus mutans
dc.subject.otherrubrolides
dc.subject.otherBiofilm inhibition
dc.titleChemical, microscopic, and microbiological analysis of a functionalizedpoly-ether-ether-ketone-embedding antibiofilm compounds
dc.typeArtigo de periódico
local.citation.epage3020
local.citation.issue12
local.citation.spage3015
local.citation.volume104
local.description.resumoPoly-ether-ether-ketone (PEEK) is currently introduced as an alternative material for orthopedic implants due to its biocompatibility and low elastic modulus compared to titanium. Also, a sulphonation treatment can functionalize PEEK to embed therapeutical substances. The objective of this work was to functionalize a PEEK film to incorporate novel lactam-based antibiofilms compounds. PEEK samples were functionalized by sulphuric acid treatment and then dissolved in dimethylsulfoxide, where lactams were added to be incorporated into the polymer. A dip-coating technique was used to synthesize a thin film on a glass-based substrate. The degree of sulfonation (DS) and the incorporation of lactams into sulphonated PEEK (sPEEK) were analyzed by Fourier transform infrared spectroscopy, nuclear magnetic resonance, thermogravimetric analysis (TGA), and scanning electron microscopy. A DS of 65% was obtained and TGA curves confirmed the presence of SO3H and lactams in the sPEEK structure. The growth of Streptococcus mutans biofilm decreased on sPEEK surface containing lactams when compared to sPEEK free of lactams. That indicated the antibiofilm activity of those compounds was maintained after incorporation into sPEEK. Planktonic growth analysis showed no long distant effects of sPEEK containing lactams, indicating that no systemic effects should be expected upon clinical uses of medical devices produced with lactam-treated sPEEK. Results revealed that inclusion of lactams into sPEEK represents a good alternative for the production of biomaterials resistant to bacterial accumulation.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.35842

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