The role of il10 and il17 gene polymorphisms in treatment response in children and adolescents with severe asthma

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dc.creatorMarianaisadora Ribeiro Vieira
dc.creatorMônica Versiani Nunes Pinheiro de Queiroz
dc.creatorMaria Borges Rabelo de Santana
dc.creatorHatilla Dos Santos Silva
dc.creatorAlmirane Oliveira
dc.creatorCamila Alexandrina Viana Figueiredo
dc.creatorEduardo Martín Tarazona Santos
dc.creatorRyan Dos Santos Costa
dc.creatorMaria de Lima Belizário Facury Lasmar
dc.date.accessioned2025-02-04T20:17:39Z
dc.date.accessioned2025-09-09T00:03:58Z
dc.date.available2025-02-04T20:17:39Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doi10.36416/1806-3756/e20230092
dc.identifier.issn18063756
dc.identifier.urihttps://hdl.handle.net/1843/79658
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJornal Brasileiro de Pneumologia
dc.rightsAcesso Aberto
dc.subjectPolymorphism, Genetic
dc.subjectInterleukin-10
dc.subjectInterleukin-17
dc.subjectAsthma
dc.subject.otherPolymorphism, Genetic
dc.subject.otherInterleukin-10
dc.subject.otherInterleukin-17
dc.subject.otherAsthma
dc.titleThe role of il10 and il17 gene polymorphisms in treatment response in children and adolescents with severe asthma
dc.typeArtigo de periódico
local.citation.epage7
local.citation.issue6
local.citation.spage1
local.citation.volume49
local.description.resumoObjective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma. Methods: This was a cross-sectional study, nested within a prospective cohort study of patients with severe asthma. Two outcomes were evaluated: asthma control and bronchodilator reversibility. We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024and rs2275913 in the IL17A gene; and rs3024498 in the IL10 gene. For the association analyses, we performed logistic regression in three genetic models (allelic, additive, and dominant). Results: The rs3024498 C allele in the IL10 gene was associated with failure to achieve asthma control despite regular treatment (p = 0.02). However, the G allele of the IL17A rs3819024 polymorphism was associated with failure to respond to stimulation with a β2 agonist. The rs2275913 polymorphism of the IL17A gene showed no relationship with asthma control or bronchodilator reversibility. Conclusions: In pediatric patients with severe asthma, the IL10 polymorphism appears to be associated with failure to achieve clinical control, whereas the IL17A polymorphism appears to be associated with a worse bronchodilator response. Knowledge of the involvement of these polymorphisms opens future directions for pharmacogenetic studies and for the implementation of individualized therapeutic management of severe asthma in pediatric patients.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.36416/1806-3756/e20230092

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