Epidemiological dynamics of SARS-CoV-2 VOC Gamma in Rio de Janeiro, Brazil

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dc.creatorFilipe Romero Rebello Moreira
dc.creatorMarcelo Calado de Paula Tôrres
dc.creatorRaíssa Mirella dos Santos Cunha da Costa
dc.creatorCássia Cristina Alves Gonçalves
dc.creatorDébora Souza Faffe
dc.creatorRafael Mello Galliez
dc.creatorOrlando da Costa Ferreira Junior
dc.creatorRenato Santana de Aguiar
dc.creatorAndré Felipe Andrade dos Santos
dc.creatorCarolina Moreira Voloch
dc.creatorTerezinha Marta Pereira Pinto Castiñeiras
dc.creatorMirela D'arc
dc.creatorAmilcar Tanuri
dc.creatorDiana Mariani
dc.creatorAlice Laschuk Herlinger
dc.creatorFrancine Bittencourt Schiffler
dc.creatorÁtila Duque Rossi
dc.creatorIsabela de Carvalho Leitão
dc.creatorThamiris dos Santos Miranda
dc.creatorMatheus Augusto Calvano Cosentino
dc.date.accessioned2023-07-15T00:17:12Z
dc.date.accessioned2025-09-08T22:59:53Z
dc.date.available2023-07-15T00:17:12Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1093/ve/veab087
dc.identifier.issn2057-1577
dc.identifier.urihttps://hdl.handle.net/1843/56354
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofVirus Evolution
dc.rightsAcesso Aberto
dc.subjectCOVID-19
dc.subjectBrasil
dc.subject.otherSARS-CoV-2
dc.subject.otherCOVID-19
dc.subject.otherVariant of concern Gamma
dc.subject.otherLineage P.1
dc.subject.otherRio de Janeiro
dc.subject.otherBrazil
dc.subject.otherPhylodynamics
dc.subject.otherPhylogeography
dc.titleEpidemiological dynamics of SARS-CoV-2 VOC Gamma in Rio de Janeiro, Brazil
dc.typeArtigo de periódico
local.citation.epage11
local.citation.issue2
local.citation.spage1
local.citation.volume7
local.description.resumoThe emergence and widespread circulation of severe acute respiratory syndrome coronavirus 2 variants of concern (VOCs) or interest impose an enhanced threat to global public health. In Brazil, one of the countries most severely impacted throughout the pandemic, a complex dynamics involving variants co-circulation and turnover events has been recorded with the emergence and spread of VOC Gamma in Manaus in late 2020. In this context, we present a genomic epidemiology investigation based on samples collected between December 2020 and May 2021 in the second major Brazilian metropolis, Rio de Janeiro. By sequencing 244 novel genomes through all epidemiological weeks in this period, we were able to document the introduction and rapid dissemination of VOC Gamma in the city, driving the rise of the third local epidemic wave. Molecular clock analysis indicates that this variant has circulated locally since the first weeks of 2021 and only 7 weeks were necessary for it to achieve a frequency above 70per cent, consistent with rates of growth observedinManausandotherstates.Moreover,aBayesianphylogeographicreconstructionindicatesthatVOCGammaspreadthroughout Brazil between December 2020 and January 2021 and that it was introduced in Rio de Janeiro through at least 13 events coming from nearly all regions of the country. Comparative analysis of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) cycle threshold (Ct) values provides further evidence that VOC Gamma induces higher viral loads (N1 target; mean reduction of Ct: 2.7, 95percentconfidenceinterval=±0.7).Thisanalysiscorroboratesthepreviouslyproposedmechanisticbasisforthisvariant-enhanced transmissibility and distinguished epidemiological behavior. Our results document the evolution of VOC Gamma and provide independent assessment of scenarios previously studied in Manaus, therefore contributing to the better understanding of the epidemiological dynamics currently being surveyed in other Brazilian regions.
local.identifier.orcidhttps://orcid.org/0000-0002-7162-5070
local.identifier.orcidhttps://orcid.org/0000-0001-6587-3871
local.identifier.orcidhttps://orcid.org/0000-0003-2970-7889
local.identifier.orcidhttps://orcid.org/0000-0001-5255-5938
local.identifier.orcidhttps://orcid.org/0000-0003-0348-8374
local.identifier.orcidhttps://orcid.org/0000-0002-1970-8936
local.identifier.orcidhttps://orcid.org/0009-0001-0494-2631
local.identifier.orcidhttps://orcid.org/0000-0001-5182-4366
local.identifier.orcidhttps://orcid.org/0000-0002-4746-6049
local.identifier.orcidhttps://orcid.org/0000-0003-3644-0246
local.identifier.orcidhttps://orcid.org/0000-0003-1382-9988
local.identifier.orcidhttps://orcid.org/0000-0002-7660-7058
local.identifier.orcidhttps://orcid.org/0000-0002-6177-163X
local.identifier.orcidhttps://orcid.org/0000-0001-6235-8807
local.identifier.orcidhttps://orcid.org/0000-0001-7919-612X
local.identifier.orcidhttps://orcid.org/0000-0001-9372-6561
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/ve/article/7/2/veab087/6378621?login=true

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