Interleukin-10 promoter gene polymorphisms are associated with the first major depressive episode in chronic hepatitis C patients

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dc.creatorLuciana Rodrigues da Cunha
dc.creatorOlindo Assis Martins Filho
dc.creatorDulciene Maria de Magalhães Queiroz
dc.creatorFernando Silva Neves
dc.creatorLuciana Diniz Silva
dc.creatorDiego Alves Vieira
dc.creatorYala Gramigna Giampietro
dc.creatorAdriana Dias Gomes
dc.creatorCésar Lúcio Lopes de Faria jr
dc.creatorFabrício Freire de Melo
dc.creatorRosângela Teixeira
dc.creatorAndrea Teixeira de Carvalho
dc.creatorLuciana Maria Oliveira
dc.creatorGifone Aguiar Rocha
dc.date.accessioned2023-07-12T22:57:27Z
dc.date.accessioned2025-09-09T00:32:04Z
dc.date.available2023-07-12T22:57:27Z
dc.date.issued2018-10-24
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.clinre.2018.11.015
dc.identifier.issn22107401
dc.identifier.urihttps://hdl.handle.net/1843/56158
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinics and Research in Hepatology and Gastroenterology
dc.rightsAcesso Restrito
dc.subjectHepatite C Crônica
dc.subjectDepressão
dc.subjectProteína Ribossômica L10
dc.subject.otherATA haplotype
dc.subject.otherChronic hepatitis C
dc.subject.otherDepression
dc.subject.otherFirst major depressive episode
dc.subject.otherIL10 gene polymorphisms
dc.subject.otherIL10 SNPs
dc.titleInterleukin-10 promoter gene polymorphisms are associated with the first major depressive episode in chronic hepatitis C patients
dc.typeArtigo de periódico
local.citation.epage426
local.citation.spage417
local.citation.volume43
local.description.resumoAims: To investigate the association of IL10 SNPs in chronic hepatitis C (CHC) patients with and without the first major depressive episode (MDE), as well as their association with plasma levelsof target cytokines. Methods: A hundred and thirty two CHC patients (32 with and 100 without first MDE) and 98 controls were prospectively enrolled in this cross-sectional study. MDE was diagnosed by a psy chiatrist, using the Mini International Neuropsychiatric Interview Plus 5.0. IL10 polymorphi (−1082G/A, −819C/T and −592C/A IL10 SNPs) were evaluated by Taqman SNP genotyping assay.Plasma concentrations of IL-2, IL-6, IL-10, IFN-y and TNF-a were determined using the HumanTh1/Th2 Cytometric Bead Array kit. The associations were investigated by logistic models.Results: The frequencies of the studied IL10 SNPs did not differ between the CHC patients and controls. The first MDE was positive and independently associated with the IL10-1082*A, IL10-819*T and IL10-592*A (ATA) low producer haplotype (OR = 1.50; 95% CI = 1.11—2.04; P = 0.009) and current alcohol misuse (OR = 4.29; 95% CI = 1.22—15.05; P = 0.02), and inversely associated with increasing age (OR = 0.94; 95% CI = 0.91—0.98; P = 0.006). In addition, plasma level of TNF- was significantly higher in the carriers than in the non-carriers of the IL10 ATA haplotype in patients with the first MDE. The IL-10 and IL-2 plasma levels were significantly higher in the carriers than in non carriers of the IL10 GCC high producer haplotype, demonstrating the functionality of the studied IL10 polymorphisms. Conclusions: This is the first study to demonstrate that the IL10 low producer ATA haplotype is associated with the first MDE in patients with CHC.
local.identifier.orcidhttps://orcid.org/0000-0003-2757-1375
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S2210740118302766?via%3Dihub

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