Evolution tumour models paving the way for understanding oral carcinogenesis

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dc.creatorRoberta Rayra Martins-Chaves
dc.creatorRubens Signoretti Oliveira Silva
dc.creatorThaís dos Santos Fontes Pereira
dc.creatorFelipe Paiva Fonseca
dc.creatorRicardo Santiago Gomez
dc.date.accessioned2024-12-06T20:48:59Z
dc.date.accessioned2025-09-09T00:48:49Z
dc.date.available2024-12-06T20:48:59Z
dc.date.issued2023
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.13402
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/78516
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectMouth neoplasms
dc.subjectPathology, molecular
dc.subjectMouth mucosa
dc.subjectOdontodysplasia
dc.subjectCarcinogenesis
dc.subject.otherMolecular pathology
dc.subject.otherOral cancer
dc.subject.otherOral mucosa
dc.subject.otherOral precancer
dc.subject.otherPotentially malignant disorders
dc.titleEvolution tumour models paving the way for understanding oral carcinogenesis
dc.typeArtigo de periódico
local.citation.epage299
local.citation.issue4
local.citation.spage294
local.citation.volume52
local.description.resumoThroughout the centuries, the world's outstanding scientists and research groups have gathered their efforts to characterise the initiation and progression of malignant neoplasms. The temporal dissection of tumourigenesis provided by phylogenetic studies is one of the milestones in understanding cancer; however, some black boxes are still unsolved. Currently, there is no consensus regarding the development of oral squamous cell carcinoma (OSCC), the leading cancer of the head and neck region. Oral epithelial dysplasia (OED) may precede oral cancer and, occasionally, be clinically evident as white, red or mixed mucosal lesions, called oral potentially malignant disorders (OPMD). In a stepwise view of oral carcinogenesis, OED and OPMD have been considered harbingers of oral cancer. Nevertheless, the malignant transformation of OPMD is a rare event. Most of these disorders remain benign and can even regress, making it challenging to formulate evolutionary hypotheses for OSCC initiation. Deciphering OED evolution is vital to highlight the potential drivers of oral carcinogenesis and molecular targets for OSCC preventative and therapeutic strategies. This narrative review synthesises the main concepts of evolutionary theories and discusses which of them better explains OED development and malignant transformation.
local.identifier.orcidhttps://orcid.org/0000-0001-6182-9232
local.identifier.orcidhttps://orcid.org/0000-0001-9524-8604
local.identifier.orcidhttps://orcid.org/0000-0002-6657-4547
local.identifier.orcidhttps://orcid.org/0000-0001-8770-8009
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13402

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