Lactococcus lactis and resveratrol decrease body weight and increase benefic gastrointestinal microbiota in mice

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dc.creatorKeila Lopes Mendes
dc.creatorDeborah de Farias Lelis
dc.creatorLetícia Antunes Athayde Souza
dc.creatorRonize Viviane Jorge Brito
dc.creatorMariléia Chaves Andrade
dc.creatorSérgio Avelino Mota Nobre
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorJuliana Pinto de Lima
dc.creatorAline Hilzendeger
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-09-05T13:47:15Z
dc.date.accessioned2025-09-09T01:28:34Z
dc.date.available2022-09-05T13:47:15Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doi10.2174/0929866527999201209214850
dc.identifier.issn1875-5305
dc.identifier.urihttps://hdl.handle.net/1843/44904
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProtein and Peptide Letters
dc.rightsAcesso Restrito
dc.subjectProbióticos
dc.subjectFitonutrientes
dc.subjectFenóis
dc.subjectSistema imunológico
dc.subjectPeso corporal
dc.titleLactococcus lactis and resveratrol decrease body weight and increase benefic gastrointestinal microbiota in mice
dc.typeArtigo de periódico
local.citation.epage768
local.citation.issue7
local.citation.spage761
local.citation.volume28
local.description.resumoBackground: the microbiome is now known for its important role in whole-body homeostasis. A dysbiosis of the normal microbiota is correlated with metabolic disorders. In this sense, the search for compounds able to modulate the microbiome is needed. Resveratrol, a natural compound found in grapes seems to be a promising candidate. Objective: in this study, our motivation was to evaluate the effects of the association between Resveratrol and Lactococcus lactis, a probiotic, on the composition of the gastrointestinal microbiota and body weight of mice. Methods: twenty female mice were divided into 4 groups: (1) standard diet, (2) standard diet plus Lactococcus lactis, (3) standard diet plus resveratrol, and (4) standard diet plus Lactococcus lactis and resveratrol. At the end of the treatment period, samples of blood, mucus, stomach, and small and large intestines were collected for analysis. Total levels of Immunoglobulin A and Immunoglobulin E, Lac+ and Lac- bacteria and Lactobacillus were measured. Results: the main results indicate that the association between resveratrol and probiotics was able to decrease mice body weight, as compared to the other groups, in addition to decrease the number of Lac- bacteria and increasing the number of Lac+ bacteria. The levels of secretory IgA were also decreased, compared to the animals treated with only probiotics or resveratrol. Conclusion: we observed potential synergism between Resveratrol and Lactococcus lactis mainly in modulating the stomach and intestinal microbiota.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.eurekaselect.com/article/112265

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