Impact of multisection and immunohistochemistry in lymph node staging of Gastric Carcinoma – Case series

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dc.creatorFernando A. V. Santos
dc.creatorAna P. Drummond-lage
dc.creatorAlberto J. A. Wainstein
dc.creatorMarco A. Dias-filho
dc.creatorPaulo R. Savassi-rocha
dc.creatorTúlio Pinho Navarro
dc.date.accessioned2023-07-18T19:50:05Z
dc.date.accessioned2025-09-09T00:57:02Z
dc.date.available2023-07-18T19:50:05Z
dc.date.issued2020-02-24
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1038/s41598-020-59000-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/56610
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectImuno-Histoquímica
dc.subjectCarcinoma
dc.subject.otherImuno-Histoquímica
dc.subject.otherCarcinoma
dc.titleImpact of multisection and immunohistochemistry in lymph node staging of Gastric Carcinoma – Case series
dc.typeArtigo de periódico
local.citation.epage8
local.citation.issue1
local.citation.spage1
local.citation.volume10
local.description.resumoGastric carcinoma (GC) locoregional recurrence may occur even in cases where the tumor has been completely resected, possibly due to lymph node (LN) micrometastases. It is estimated that in 10% to 30% of cases, LN micrometastases are not detected by a conventional method for histological assessment of LN metastases with hematoxylin-eosin (HE). A cross-sectional study assessed 51 patients with GC by histological evaluation of the LN micrometastases through LN multi sectioning associated with immunohistochemistry analysis with monoclonal antibodies AE1 and AE3. Total gastrectomy was performed in 51% of patients. The total number of resected LN nodes was 1698, with a mean number of resected LN of 33.3 ± 13.2 per surgical specimen, of which 187 had metastasis. After the application of LN multisection and immunohistochemistry, LN micrometastases were found in 45.1% of the cases. LN staging changed in 29.4%, and tumor staging changed in 23.5% of the cases. In patients initially staged as pN0, LN staging and tumor staging changed, both in 19.2% of the cases. In patients initially staged as pN1 or more, LN staging changed in 40.0% of them, and tumor staging changed in 28.0% of the cases. The accuracy of HE for the histological staging of LN tumoral involvement was 76%, which was considered insufficient for CG patients staging. Investigation of LN micrometastasis through LN multisection and immunohistochemistry should be performed, particularly in cases where the presence of blood and lymphatic vessel invasion has been identified after conventional histological analysis, as well as in patients with advanced GC.
local.identifier.orcidhttp://orcid.org/0000-0003-0289-8953
local.identifier.orcidhttp://orcid.org/0000-0002-8227-7972
local.identifier.orcidhttps://orcid.org/0000-0001-8134-5825
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-020-59000-8#rightslink

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