The aspergillus fumigatus mucin msba regulates the cell wall integrity pathway and controls recognition of the fungus by the immune system

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dc.creatorIsabella Luisa da Silva Gurgel
dc.creatorFrederico Marianetti Soriani
dc.creatorKarina Talita de Oliveira Santana Jorge
dc.creatorNathália Luisa Sousa de Oliveira Malacco
dc.creatorJéssica Amanda Marques Souza
dc.creatorMarina Campos Rocha
dc.creatorMarina Faria Fernandes
dc.creatorFlávia Rayssa Braga Martins
dc.creatorIran Malavazi
dc.creatorMauro Martins Teixeira
dc.date.accessioned2023-07-14T22:48:01Z
dc.date.accessioned2025-09-08T23:41:53Z
dc.date.available2023-07-14T22:48:01Z
dc.date.issued2019
dc.identifier.doihttps://doi.org/10.1128/msphere.00350-19
dc.identifier.issn2379-5042
dc.identifier.urihttps://hdl.handle.net/1843/56333
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAmerican Society for Microbiology
dc.rightsAcesso Aberto
dc.subjectBiologia
dc.subjectAspergillus fumigatus
dc.subjectParedes celular fúngica
dc.subject.otherAspergillus fumigatus
dc.subject.otherCell wall integrity
dc.subject.otherImmune response
dc.subject.otherMSB2
dc.subject.otherMucin
dc.subject.otherVirulence
dc.titleThe aspergillus fumigatus mucin msba regulates the cell wall integrity pathway and controls recognition of the fungus by the immune system
dc.typeArtigo de periódico
local.citation.epage15
local.citation.issue3
local.citation.spage1
local.citation.volume4
local.description.resumoAspergillus fumigatus is a filamentous fungus which causes invasive pulmonary aspergillosis in immunocompromised individuals. In fungi, cell signaling and cell wall plasticity are crucial for maintaining physiologic processes. In this context, Msb2 is an important signaling mucin responsible for activation of a variety of mitogen-activated protein kinase (MAPK)-dependent signaling pathways that regulate cell growth in several organisms, such as the cell wall integrity (CWI) pathway. Here, we aimed to characterize the MSB2 homologue in A. fumigatus. Our results showed that MsbA plays a role in the vegetative and reproductive development of the fungus, in stress adaptation, and in resistance to antifungal drugs by modulating the CWI pathway gene expression. Importantly, cell wall composition is also responsible for activation of diverse receptors of the host immune system, thus leading to a proper immune response. In a model of acute Aspergillus pulmonary infection, results demonstrate that the ΔmsbA mutant strain induced less inflammation with diminished cell influx into the lungs and lower cytokine production, culminating in increased lethality rate. These results characterize for the first time the role of the signaling mucin MsbA in the pathogen A. fumigatus, as a core sensor for cell wall morphogenesis and an important regulator of virulence.
local.identifier.orcidhttps://orcid.org/0000-0002-1797-6080
local.identifier.orcidhttps://orcid.org/0000-0003-4720-6746
local.identifier.orcidhttps://orcid.org/0000-0002-5823-2184
local.identifier.orcidhttps://orcid.org/0000-0003-4988-7629
local.identifier.orcidhttps://orcid.org/0000-0002-4526-4961
local.identifier.orcidhttps://orcid.org/0000-0002-6944-3008
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://journals.asm.org/doi/10.1128/mSphere.00350-19

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