Screening for Zika virus RNA in sera of suspected cases: a retrospective cross-sectional study

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dc.creatorLívia Sacchetto
dc.creatorDanielle Alves Gomes Zauli
dc.creatorGalileu Barbosa Costa
dc.creatorSarah Anne Guagliardo
dc.creatorLuige Biciati Alvim
dc.creatorFeliciana Lage de Oliveira Marinho
dc.creatorLuige Biciati Alvim
dc.creatorFeliciana Lage de Oliveira Marinho
dc.creatorJônatas Santos Abrahão
dc.creatorGiliane de Souza Trindade
dc.creatorErna Geessien Kroon
dc.creatorElvis Cristian Cueva Mateo
dc.creatorBetânia Paiva Drumond
dc.date.accessioned2025-02-10T21:20:46Z
dc.date.accessioned2025-09-08T23:16:56Z
dc.date.available2025-02-10T21:20:46Z
dc.date.issued2018-10-11
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1186/s12985-018-1070-z
dc.identifier.issn1743-422X
dc.identifier.urihttps://hdl.handle.net/1843/79843
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofVirology Journal
dc.rightsAcesso Aberto
dc.subjectZika virus
dc.subjectEpidemiologia
dc.subjectVírus Chikungunya
dc.subjectBrasil
dc.subjectVírus da Dengue
dc.subject.otherZika virus
dc.subject.otherCross-sectional study
dc.subject.otherEpidemiology
dc.subject.otherBrazil
dc.subject.otherChikungunya virus
dc.subject.otherDengue virus
dc.titleScreening for Zika virus RNA in sera of suspected cases: a retrospective cross-sectional study
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume15
local.description.resumoBackground: Zika virus (ZIKV) became a global human health concern owing to its rapid spread worldwide and its association with congenital and neurological disorders. The current epidemiological profile of arboviruses in Brazil is characterized by widespread co-circulation of Dengue virus, Chikungunya virus, and ZIKV throughout the country. These viruses cause acute diseases frequently with overlapping symptoms, which could result in an inaccurate diagnosis based solely on clinical and epidemiological grounds. Here we conducted a screening for ZIKV RNA in serum samples from patients across Brazil with suspected ZIKV infection. Methods: Using RT-qPCR, we investigated ZIKV RNA in 3001 serum samples. Samples were passively acquired through a private laboratory network, between December 2015 and August 2016, from 27 Brazilian Federative Units. We performed descriptive statistics on demographic variables including sex, age, and geographic location. Results: ZIKV was detected in 11.4% (95%CI = 10.3–12.6%) of the sera. ZIKV RNA was detected in sera collected throughout the country, but during the analyzed period, RNA was more frequently detected in samples from the Southeast, Midwest, and North regions (3.9 to 5.8 times higher) when compared to the Northeast and South regions. Conclusions: These data reinforce the importance of laboratory diagnosis, surveillance systems, and further epidemiological studies to understand the dynamics of outbreaks and diseases associated with ZIKV and other arboviruses.
local.identifier.orcidhttps://orcid.org/0000-0001-9716-6899
local.identifier.orcidhttps://orcid.org/0000-0001-7360-6722
local.identifier.orcidhttps://orcid.org/0000-0002-4217-8195
local.identifier.orcidhttps://orcid.org/0000-0003-3432-8146
local.identifier.orcidhttps://orcid.org/0000-0001-6691-6386
local.identifier.orcidhttps://orcid.org/0000-0001-9420-1791
local.identifier.orcidhttps://orcid.org/0000-0003-0785-4298
local.identifier.orcidhttps://orcid.org/0000-0003-2721-3826
local.identifier.orcidhttps://orcid.org/0000-0001-5880-2557
local.identifier.orcidhttps://orcid.org/0000-0002-4049-4055
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://virologyj.biomedcentral.com/articles/10.1186/s12985-018-1070-z#rightslink

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