Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4

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dc.creatorDiana Paola Gómez-Mendoza
dc.creatorFúlvia Dias Marques
dc.creatorMarcella Nunes de Melo Braga
dc.creatorRichard Remko Sprenger
dc.creatorRubén Dario Sinisterra Millán
dc.creatorFrank Kjeldsen
dc.creatorRobson Augusto Souza dos Santos
dc.creatorThiago Verano-Braga
dc.date.accessioned2023-11-21T20:13:07Z
dc.date.accessioned2025-09-08T23:39:48Z
dc.date.available2023-11-21T20:13:07Z
dc.date.issued2019-09
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.identifier.doihttps://doi.org/10.1016/j.jprot.2019.103486
dc.identifier.issn1876-7737
dc.identifier.urihttps://hdl.handle.net/1843/61210
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Proteomics
dc.rightsAcesso Restrito
dc.subjectAngiotensina
dc.subjectEnfarte do miocárdio
dc.subjectAgentes antiinflamatórios
dc.subjectCiclodextrinas
dc.subject.otherAngiotensin-(1–7)
dc.subject.otherAnti-inflammatory
dc.subject.otherMyocardial infarction
dc.subject.otherProteomics
dc.subject.otherCXCR4
dc.titleAngiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4
dc.typeArtigo de periódico
local.citation.volume208
local.description.resumoMyocardial infarction triggers cellular events that starts with the activation of inflammatory response and fibrogenic pathways involved in cardiac tissue remodeling. Angiotensin-(1–7) (Ang-(1–7)) is an endogenous heptapeptide from the renin-angiotensin system with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Although the beneficial aspects of Ang-(1–7) in animal models of cardiac ischemia have been reported, the molecular events underlying Ang-(1–7) cardioprotective effect remains elusive. This study investigated the impact of oral treatment with Ang-(1–7) included in hydroxypropyl β-cyclodextrin (HPβCD/Ang-(1–7)) on the cardiac proteome dysregulation due to experimental myocardial infarction. Wistar male rats were submitted to experimental myocardial infarction and treated daily with HPβCD/Ang-(1–7) during 7 days or 60 days by gavage. Our results showed that HPβCD/Ang-(1–7) treatment ameliorates the post-infarction condition due to the modulation of proteins that initially favor the resolution of inflammation and mitochondrial dysfunction. Moreover, this study reported for the first time that Ang-(1–7) treatment after experimental myocardial infarction leads to the downregulation of the C-X-C chemokine receptor type 4 (CXCR4).
local.identifier.orcidhttps://orcid.org/0000-0003-3318-3539
local.identifier.orcidhttps://orcid.org/0000-0002-6174-8157
local.identifier.orcidhttps://orcid.org/0000-0002-3947-1606
local.identifier.orcidhttps://orcid.org/0000-0001-7656-1849
local.identifier.orcidhttps://orcid.org/0000-0003-0785-2903
local.identifier.orcidhttps://orcid.org/0000-0002-7083-2588
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1874391919302581

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