Physical and biological effects of paclitaxel encapsulation on disteraroylphosphatidylethanolamine-polyethyleneglycol polymeric micelles

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dc.creatorCaroline Mari Ramos Oda
dc.creatorAntonio Augusto Malfatti Gasperini
dc.creatorÂngelo Malachias de Souza
dc.creatorGwenaelle Elza Nathalie Pound-Lana
dc.creatorVanessa Carla Furtado Mosqueira
dc.creatorRenata Salgado Fernandes
dc.creatorMônica Cristina de Oliveira
dc.creatorAndré Luís Branco de Barros
dc.creatorElaine Amaral Leite
dc.date.accessioned2023-04-04T13:34:23Z
dc.date.accessioned2025-09-08T23:21:24Z
dc.date.available2023-04-04T13:34:23Z
dc.date.issued2020
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.colsurfb.2019.110760
dc.identifier.issn1873-4367
dc.identifier.urihttps://hdl.handle.net/1843/51540
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofColloids and Surfaces B: Biointerfaces
dc.rightsAcesso Restrito
dc.subjectCâncer
dc.subject.otherPolymeric micelles
dc.subject.otherPaclitaxel
dc.subject.otherCancer
dc.titlePhysical and biological effects of paclitaxel encapsulation on disteraroylphosphatidylethanolamine-polyethyleneglycol polymeric micelles
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume188
local.description.resumoSimple size observations of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) polymeric micelles (PM) with different compositions including or not paclitaxel (PTX) are unable to evidence changes on the nanocarrier structure. In such system a detailed characterization using highly sensitive techniques such as X-ray scattering and asymmetric flow field flow fractionation coupled to multi-angle laser light scattering and dynamic light scattering (AF4-MALS-DLS) is mandatory to observe effects that take place by the addition of PTX and/or more lipid-polymer at PM, leading to complex changes on the structure of micelles, as well as in their supramolecular organization. SAXS and AF4-MALS-DLS suggested that PM can be found in the medium separately and highly organized, forming clusters of PM in the latter case. SAXS fitted parameters showed that adding the drug does not change the average PM size since the increase in core radius is compensated by the decrease in shell radius. SAXS observations indicate that PEG conformation takes place, changing from brush to mushroom depending on the PM composition. These findings directly reflect in in vivo studies of blood clearance that showed a longer circulation time of blank PM when compared to PM containing PTX.
local.identifier.orcidhttps://orcid.org/0000-0002-7449-5400
local.identifier.orcidhttps://orcid.org/0000-0002-8703-4283
local.identifier.orcidhttps://orcid.org/0000-0003-0569-0242
local.identifier.orcidhttps://orcid.org/0000-0002-0368-6090
local.identifier.orcidhttps://orcid.org/0000-0002-7641-6585
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S092777651930904X

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