Burkitt lymphoma of the head and neck: an international collaborative study

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dc.creatorMário José Romañach
dc.creatorLady Paola Aristizabal Arboleda
dc.creatorLiam Robinson
dc.creatorWillie van Heerden
dc.creatorRomán Carlos
dc.creatorElena María José Román Tager
dc.creatorIva Loureiro Hoffmann
dc.creatorIzilda Aparecida Cardinalli
dc.creatorRegina Maria Holanda Mendonça
dc.creatorMarianne Vasconcelos Carvalho
dc.creatorAllan Vinícius Martins-de-Barros
dc.creatorAndré Caroli Rocha
dc.creatorCarla Isabelly Rodrigues-Fernandes
dc.creatorSyed Ali Khurram
dc.creatorPaul Speight
dc.creatorMarcio Ajudarte Lopes
dc.creatorPablo Agustin Vargas
dc.creatorOslei Paes Almeida
dc.creatorAlan Roger Santos-Silva
dc.creatorBruno Augusto Linhares Almeida Mariz
dc.creatorBruno Augusto Benevenuto Andrade
dc.creatorAline Corrêa Abrahão
dc.creatorMichelle Agostini
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorFelipe Paiva Fonseca
dc.date.accessioned2023-12-04T21:01:09Z
dc.date.accessioned2025-09-08T22:52:34Z
dc.date.available2023-12-04T21:01:09Z
dc.date.issued2021
dc.identifier.doihttps://doi.org/10.1111/jop.13209
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/61688
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectBurkitt lymphoma
dc.subjectHead
dc.subjectNeck
dc.subjectLymphoma, non-Hodgkin
dc.subjectPediatrics
dc.subjectImmunohistochemistry
dc.subject.otherLinfoma
dc.subject.otheracesso restrito fao clínica Burkitt lymphoma of the head and neck: an international collaborative study título periódico Journal of oral pathology & medicine assunto Burkitt Lymphoma busca dia 28/11/2023
dc.titleBurkitt lymphoma of the head and neck: an international collaborative study
dc.typeArtigo de periódico
local.citation.epage586
local.citation.issue6
local.citation.spage572
local.citation.volume50
local.description.resumoBackground: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with three variants (endemic, sporadic, and immunodeficiency-associated), presenting with specific epidemiological and clinical features. Burkitt lymphoma affects the head and neck region (BLHN) in approximately 10% of cases. The aim of this study was to undertake a comparative analysis of the clinicopathologic and immunohistochemical (IHC) features of BLHN diagnosed in patients from Africa, Guatemala, and Brazil. Methods: Cases diagnosed as BLHN were collected from the files of six oral pathology laboratory services (Brazil, South Africa, and Guatemala) and one Brazilian pediatric oncology hospital from 1986 to 2020. Clinicopathological and IHC data, and Epstein-Barr virus (EBV) status by in situ hybridization data for each case were reviewed and described. Results: Of the 52 cases, BLHN was predominant in pediatric patients [43 (82.69%)] and males [43 (82.69%)], with a mean age of 11.26 ± 9.68 years (range, 1-39 years). Neck and cervical lymph nodes [14 (26.92%)], and involvement of both maxilla and mandible [8 (15.38%)], were the most common anatomical sites. Clinically, tumor/swelling [40 (31.25%)], cervical lymphadenopathy [14 (10.94%)], pain [12 (9.38%)], and bone destruction [12 (9.38%)] were frequent findings. All cases showed typical morphological characteristics of BL. IHC profiles included positivity for CD20 [52 (100%)], CD10 [38 (79.17%)], Bcl6 [29 (87.88%)], and c-Myc protein [18 (81.82%)]. EBV was positive in 18 cases (62.07%). The Ki-67 index ranged from 90 to 100%.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13209

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