Characterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae

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dc.creatorEmerson Ribeiro Lima
dc.creatorL. L. S. Cardoso
dc.creatorAlessandra Rejane Ericsson de Oliveira Xavier
dc.creatorAdriana Amaral Carvalho
dc.creatorMauro Aparecido de Sousa Xavier
dc.creatorHadison Santos Nogueira Curzio
dc.creatorHigor Rabelo Guedes
dc.creatorLuciano Freitas Fernandes
dc.creatorAnna Christina de Almeida
dc.creatorElytania Veiga Menezes
dc.creatorNair Amélia Prates Barreto
dc.date.accessioned2022-06-08T11:36:06Z
dc.date.accessioned2025-09-09T01:16:59Z
dc.date.available2022-06-08T11:36:06Z
dc.date.issued2019
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttp://doi.org/10.4238/GMR18172
dc.identifier.issn1676-5680
dc.identifier.urihttps://hdl.handle.net/1843/42345
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofGenetics and Molecular Research
dc.rightsAcesso Aberto
dc.subjectBacterias gram-negativas
dc.subjectInfecções por Bactérias Gram-Negativas
dc.titleCharacterization and molecular epidemiology of extensively prevalent nosocomial isolates of drug-resistant klebsiella pneumoniae
dc.typeArtigo de periódico
local.citation.issue1
local.citation.volume18
local.description.resumoWe characterized six drug-resistant nosocomial isolates of Klebsiella pneumoniae obtained in a hospital located in northern Minas Gerais State, Brazil, by determining their antibiotic sensitivity profiles, detecting the blaKPC genetic marker and examining their clonal relationships. All isolates were found to be extensively drug resistant. A PCR assay was used to confirm the identity of the isolates as K. pneumoniae and assess the blaKPC gene. All isolates tested positive for the blaKPC gene, which is related to carbapenem resistance. The genetic profiles and clonal relationships among the isolates were evaluated by ERIC-PCR. All the isolates were in a single group with two distinct subgroups. Analysis of the genetic diversity among the isolates revealed that five of the six were clones, which suggests cross-transmission in this hospital environment. Five of the patients died from infection. We describe the first detection of KPC-producing K. pneumoniae isolates from a hospital in northern Minas Gerais state.
local.identifier.orcidhttps://orcid.org/ 0000-0001-9836-4117
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.semanticscholar.org/paper/Research-Article-Characterization-and-molecular-of-Lima-Carvalho/ec00cd9bc4ae45027c20664729630a997b7218ca

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