Propolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study

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dc.creatorVagner Rodrigues Santos
dc.creatorEvandro Neves Abdo
dc.creatorFernando Paolinelli Carvalho Leite Pérsio
dc.creatorVladimir Reimar Augusto de Souza Noronha
dc.date.accessioned2025-06-16T20:32:37Z
dc.date.accessioned2025-09-09T00:02:24Z
dc.date.available2025-06-16T20:32:37Z
dc.date.issued2017-03
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://www.oatext.com/Propolis-gel-versus-benzydamine-in-preventing-oral-mucositis-for-patients-irradiated-in-head-and-neck-a-preliminary-study.php#:~:text=10.15761/CRR.1000112
dc.identifier.issn2513-9290
dc.identifier.urihttps://hdl.handle.net/1843/82993
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCancer Reports and Reviews
dc.rightsAcesso Aberto
dc.subjectMedical oncology
dc.subjectMucositis
dc.subjectRadiotherapy
dc.subjectConsolidation chemotherapy
dc.subjectPropolis
dc.subjectEfficacy
dc.subjectEvaluation study
dc.subjectStomatitis
dc.subjectBenzydamine
dc.subject.otherMucositis
dc.subject.otherOncology
dc.subject.otherRadiotherapy
dc.subject.otherChemotherapy
dc.subject.otherPropolis
dc.titlePropolis gel versus benzydamine in preventing oral mucositis for patients irradiated in head and neck: a preliminary study
dc.typeArtigo de periódico
local.citation.epage4
local.citation.issue2
local.citation.spage1
local.citation.volume1
local.description.resumoOral Mucositis refers to oral mucosa erythematous and ulcerative lesions and is caused by radiation dispensed in the treatment of malignant tumors of the head and neck. Propolis shows several biological activities such as antimicrobial and anti-inflammatory properties. These biological activities should prevent a mucositis. The aim is to verify the effectiveness of Brazilian green propolis in a mucoadhesive gel, alcohol free, in preventing oral mucositis in patients that underwent radiotherapy. This research is characterized as a preliminary study with a mean duration of 12 weeks of patients’ follow-up in two groups. The selection of participant’s groups was randomized. The 26 selected patients were distributed between two groups, 13 in the benzydamine group and 13 in the propolis group. Patients were assessed on an average of 4.5 times totaling 116 diagnoses of mucositis. The percentage of patients who had mucositis greater or equal to 2 in this study was 30.6% for the benzydamine group and 29.6% for propolis gel. For these patients, the propolis gel shows a better performance in maintaining lower rates/grades and recovery of patients from the 17th session of radiotherapy. This work shows a great possibility of further study in Phase III due to its good results and acceptance with patients.
local.identifier.orcidhttps://orcid.org/0000-0002-5370-4867
local.identifier.orcidhttps://orcid.org/0000-0002-8753-435X
local.identifier.orcidhttps://orcid.org/0000-0002-2809-0859
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.oatext.com/Propolis-gel-versus-benzydamine-in-preventing-oral-mucositis-for-patients-irradiated-in-head-and-neck-a-preliminary-study.php

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