Second harmonic generation imaging of the collagen architecture in prostate cancer tissue

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dc.creatorAloísio Miguel Garcia
dc.creatorFelipe Lima Magalhães
dc.creatorJaqueline s Soares
dc.creatorEduardo Paulino Junior
dc.creatorMário f r de Lima
dc.creatorMarcelo Mamede
dc.creatorAna m de Paula
dc.date.accessioned2023-06-21T19:50:09Z
dc.date.accessioned2025-09-09T00:12:29Z
dc.date.available2023-06-21T19:50:09Z
dc.date.issued2018-02-02
dc.identifier.doi10.1088/2057-1976/aaa379
dc.identifier.issn20571976
dc.identifier.urihttps://hdl.handle.net/1843/55202
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomedical Physics & Engineering Express
dc.rightsAcesso Restrito
dc.subjectImagem Óptica
dc.subjectMicroscopia de Geração do Segundo Harmônico
dc.subjectProstáta
dc.subjectBiópsia
dc.subject.otherOptical Imaging
dc.subject.otherSecond harmonic generation
dc.subject.otherProstate
dc.subject.otherBiopsies
dc.titleSecond harmonic generation imaging of the collagen architecture in prostate cancer tissue
dc.typeArtigo de periódico
local.citation.issue2
local.citation.volume4
local.description.resumoOptical microscopy has been one of the most important tools for visualizing biological samples since the seventeenth century. Recently, with the advances in femtosecond laser technology, all the nonlinear optical processes have now been included as optical microscopy methods, and second harmonic generation (SHG) microscopy has emerged as a powerful new optical imaging tool with applications in medicine and biology. Here we use SHG microscopy to obtain images of 76 prostate biopsies on histological slides. Multiple samples from the excised prostates of patients who underwent a radical prostatectomy were evaluated. The samples were collected from prostate positions as in needle biopsy procedures. The results show the collagen fiber architecture among malignant acini, and analysis of the fiber orientation in the images reveals that the collagen fibers become more aligned at higher malignancy grades. Furthermore, we find that the degree of fiber alignment correlates directly with the Gleason patterns.
local.identifier.orcidhttps://orcid.org/0000-0001-6157-6511
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.initialsUFMG
local.url.externahttps://iopscience.iop.org/article/10.1088/2057-1976/aaa379

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