Calm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot

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dc.creatorGabriel Quintanilha-Peixoto
dc.creatorRosimére Oliveira Torres
dc.creatorIsabella Mary Alves Reis
dc.creatorThiago Alves Santos de Oliveira
dc.creatorDener Eduardo Bortolini
dc.creatorElizabeth Amélia Alves Duarte
dc.creatorVasco Ariston de Carvalho Azevedo
dc.creatorBertram Brenig
dc.creatorEric Roberto Guimarães Rocha Aguiar
dc.creatorAna Cristina Fermino Soares
dc.creatorAristóteles Góes-Neto
dc.creatorAlexsandro Branco
dc.date.accessioned2023-06-21T20:02:34Z
dc.date.accessioned2025-09-09T00:26:24Z
dc.date.available2023-06-21T20:02:34Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.3390/toxins11110631
dc.identifier.issn2072-6651
dc.identifier.urihttps://hdl.handle.net/1843/55211
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofToxins
dc.rightsAcesso Aberto
dc.subjectAspergillus
dc.subjectMicotoxinas
dc.subject.otherPhytotoxic
dc.subject.otherMycotoxin
dc.subject.otherRed rot of sisal
dc.titleCalm before the storm: a glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the etiologic agent of the sisal bole rot
dc.typeArtigo de periódico
local.citation.issue11
local.citation.volume11
local.description.resumoAspergillus welwitschiae is a species of the Nigri section of the genus Aspergillus. In nature, it is usually a saprotroph, decomposing plant material. However, it causes the bole rot disease of Agave sisalana (sisal), a plant species used for the extraction of hard natural fibers, causing great economic loss to this culture. In this study, we isolated and sequenced one genome of A. welwitschiae (isolate CCMB 674 (Collection of Cultures of Microorganisms of Bahia)) from the stem tissues of sisal and performed in silico and wet lab experimental strategies to describe its ability to produce mycotoxins. CCMB 674 possesses 64 secondary metabolite gene clusters (SMGCs) and, under normal conditions, it produces secondary metabolism compounds that could disturb the cellular cycle of sisal or induce abnormalities in plant growth, such as malformin C. This isolate also produces a pigment that might explain the characteristic red color of the affected tissues. Additionally, this isolate is defective for the production of fumonisin B1, and, despite bearing the full cluster for the synthesis of this compound, it did not produce ochratoxin A. Altogether, these results provide new information on possible strategies used by the fungi during the sisal bole rot, helping to better understand this disease and how to control it.
local.identifier.orcidhttps://orcid.org/0000-0002-7476-5845
local.identifier.orcidhttps://orcid.org/0000-0001-5968-525X
local.identifier.orcidhttps://orcid.org/0000-0002-6582-7434
local.identifier.orcidhttps://orcid.org/0000-0002-8667-502X
local.identifier.orcidhttps://orcid.org/0000-0002-4775-2280
local.identifier.orcidhttps://orcid.org/0000-0002-7635-9656
local.identifier.orcidhttps://orcid.org/0000-0002-8143-5756
local.identifier.orcidhttps://orcid.org/0000-0002-4014-1794
local.identifier.orcidhttps://orcid.org/0000-0002-7692-6243
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIA
local.publisher.initialsUFMG
local.url.externahttps://www.mdpi.com/2072-6651/11/11/631

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