Effects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits

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dc.creatorRaquel de Oliveirameira
dc.creatorDaniel Nogueira Mendes Braga
dc.creatorLeni Safira Gonçalves Pinheiro
dc.creatorIzabela Ferreira Gontijo Amorim
dc.creatorLeonardo de Souza Vasconcellos
dc.creatorLuiz Ronaldo Alberti
dc.date.accessioned2023-11-13T19:45:41Z
dc.date.accessioned2025-09-09T01:07:05Z
dc.date.available2023-11-13T19:45:41Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doi10.1590/s0102-865020200100000006
dc.identifier.issn16782674
dc.identifier.urihttps://hdl.handle.net/1843/60890
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofActa Cirúrgica Brasileira
dc.rightsAcesso Aberto
dc.subjectPlatelet-Rich Plasma
dc.subjectRabbits
dc.subjectWound Healing
dc.subject.otherPlatelet-Rich Plasma
dc.subject.otherWound Healing
dc.subject.otherRabbits
dc.titleEffects of homologous and heterologous rich platelets plasma, compared to poor platelets plasma, on cutaneous healing of rabbits
dc.typeArtigo de periódico
local.citation.epage11
local.citation.issue10
local.citation.spage1
local.citation.volume35
local.description.resumoPurpose: To evaluate and compare the effects of homologous and heterologous PRP (Platelet-Rich Plasma) on the quality and speed of skin wound healing, compared to Poor Platelet Plasma (PPP).Methods: Twenty-one male adult rabbits were used; two for preparing homologous PRP, with the rest of them separated randomly in three groups, according to the treatment received: PPP – control (n=5), homologous PRP (n=7), heterologous (n=7). Excisional skin wounds were made on the back of the animals, for the application of homologous and heterologous PPP and PRP. At the 14th post-operative day (POD), the animals were subjected to a new wound, and the treatments were inverted. The wounds were evaluated macroscopically and histologically.Results: A larger percentage of scar retraction was observed on the group treated with heterologous PRP, compared to homologous PRP, at the third POD, an increase of 25.03% (p=0.01). No other statistically significant differences among treatments were observed. Among every group, skin healing was efficient, without local adverse effects.Conclusions: Heterologous PRP contributed with more tissue retraction at the beginning of the wound healing process. After this, there were no differences on the wound healing skin process treated with PRP or PPP. However, our findings suggest the presence of others plasmatic factors, besides platelets,which could also contribute to the wound healing process, and thus, should be further investigated.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/s0102-865020200100000006

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