Antileishmanial activity of fullerol and its liposomal formulation in experimental models of visceral leishmaniasis

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dc.creatorGuilherme Santos Ramos
dc.creatorFrederic Jean Georges Frezard
dc.creatorVirgínia Mendes Russo Vallejos
dc.creatorMarina de Souza Ladeira
dc.creatorPriscila Gomes dos Reis
dc.creatorDaniel Menezes Souza
dc.creatorLuiz Orlando Ladeira
dc.creatorMauricio Veloso Brant Pinheiro
dc.creatorMaria Norma de Melo
dc.creatorRicardo Toshio Fujiwara
dc.date.accessioned2025-07-22T16:29:19Z
dc.date.accessioned2025-09-08T23:44:50Z
dc.date.available2025-07-22T16:29:19Z
dc.date.issued2021
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2020.111120
dc.identifier.issn1950-6007
dc.identifier.urihttps://hdl.handle.net/1843/83745
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBiomedicine & Pharmacotherapy
dc.rightsAcesso Aberto
dc.subjectFuleróis
dc.subjectLipossomos
dc.subjectLeishmaniose
dc.subject.otherFullerol
dc.subject.otherFullerenol
dc.subject.otherLiposomes
dc.subject.otherLeishmaniasis
dc.subject.otherImmunomodulation
dc.subject.otherDrug delivery
dc.titleAntileishmanial activity of fullerol and its liposomal formulation in experimental models of visceral leishmaniasis
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume134
local.description.resumoVisceral leishmaniasis (VL) is a systemic parasitic disease that leads to high rates of morbidity and mortality in humans worldwide. There is a great need to develop new drugs and novel strategies to make chemotherapy for this disease more efficacious and well tolerated. Recent reports on the immunomodulatory effects and the low toxicity of the spherical carbon nanostructure fullerol led us to investigate in vitro and in vivo antileishmanial activity in free and encapsulated forms in liposomes. When assayed against intramacrophagic Leishmania amastigotes, fullerol showed a dose-dependent reduction of the infection index with IC50 of 0.042 mg/mL. When given daily by i.p. route for 20 days (0.05 mg/kg/d) in a murine model of acute VL, fullerol promoted significant reduction in the liver parasite load. To improve the delivery of fullerol to the infection sites, liposomal formulations were prepared by the dehydration-rehydration method. When evaluated in the acute VL model, liposomal fullerol (Lip-Ful) formulations given i.p. at 0.05 and 0.2 mg/kg with 4-days intervals were more effective than the free form, with significant parasite reductions in both liver and spleen. Lip-Ful at 0.2 mg/kg promoted complete parasite elimination in the liver. The antileishmanial activity of Lip-Ful was further confirmed in a chronic model of VL. Lip-Ful was also found to induce secretion of pro-inflammatory TNF-α, IFN-γ and IL-1β cytokines. In conclusion, this work reports for the first time the antileishmanial activity of fullerol and introduces an innovative approach for treatment of VL based on the association of this nanostructure with liposomes.
local.identifier.orcidhttps://orcid.org/0000-0003-3783-5717
local.identifier.orcidhttps://orcid.org/0000-0003-3505-9494
local.identifier.orcidhttps://orcid.org/0000-0001-5456-7465
local.identifier.orcidhttps://orcid.org/0000-0002-4935-6070
local.identifier.orcidhttps://orcid.org/0000-0001-5722-6260
local.identifier.orcidhttps://orcid.org/0000-0002-4713-575X
local.publisher.countryBrasil
local.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA QUÍMICA
local.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
local.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIA
local.publisher.departmentICX - DEPARTAMENTO DE FÍSICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332220313135?via%3Dihub

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