Liraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis

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dc.creatorIsabelle Arruda Barbosa
dc.creatorAndré Luiz Sena Guimarães
dc.creatorSérgio Henrique Sousa Santos
dc.creatorEloá Mangabeira Santos
dc.creatorAlanna Fernandes Paraíso
dc.creatorPablo Vinicyus Ferreira Chagas
dc.creatorLuís Paulo Oliveira
dc.creatorJoão Marcus Oliveira Andrade
dc.creatorLucyana Conceição Farias
dc.creatorBruna Mara Aparecida de Carvalho Mesquita
dc.creatorAlfredo Maurício Batista de Paula
dc.date.accessioned2022-06-20T15:30:44Z
dc.date.accessioned2025-09-09T01:15:59Z
dc.date.available2022-06-20T15:30:44Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.doihttps://doi.org/10.1016/j.mgene.2019.100553
dc.identifier.issn2214-5400
dc.identifier.urihttps://hdl.handle.net/1843/42554
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMeta Gene
dc.rightsAcesso Aberto
dc.subjectFígado gorduroso
dc.subjectSíndrome metabólica
dc.subjectObesidade
dc.subjectGenes
dc.titleLiraglutide alters hepatic metabolism in high-fat fed obese mice: a bioinformatic prediction and functional analysis
dc.typeArtigo de periódico
local.citation.volume20
local.description.resumoLiraglutide, an important pharmacological agent used to improve glycemic status and weight control, has emerged as a therapeutic strategy for hepatic steatosis treatment. Objective: The aim of the present study was to analyze the influence of liraglutide in hepatic steatosis and evaluate the potential target genes involved in the liraglutide action in the hepatic steatosis through a bioin-formatics study. Methods & procedures: We performed an animal study with male mice divided into three groups: standard, high-fat diet and the third group were fed a high-fat diet and treated with liraglutide at a dose of 0.6 mg/kg body weight. Blood parameters (glucose tolerance and insulin sensitivity tests, total cholesterol, high-density lipo-protein-C, triglycerides and glucose levels) were evaluated. mRNA analysis for ACC and FAS were performed.Gene databases, and bioinformatics algorithms were used to generate molecular targets for liraglutide and he-patic steatosis based on in silico investigation. Interactions networks between protein coding were accessed. Results: The present study showed that liraglutide decreased glucose levels, total cholesterol and triglycerides in obese animals as compared to the high-fat-fed obese mice. AKT and RPS6KB1 genes presented higher disease-related connectivity. Interaction Network exhibited a power law behavior in correlation: 0.896; R2: 0.796. Ontological analysis demonstrated different mechanisms associated such as regulation of signaling process. Conclusion: The present study reveals relevant information regarding the liraglutide effects in hepatic steatosis. The liraglutide improved hyperglycemia and attenuated hepatic steatosis in mice fed a high-fat diet.
local.identifier.orcidhttps://orcid.org/ 0000-0001-8980-8599
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S221454001930012X

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