Solid-state properties of pink clay from Jequitinhonha valley in Brazil for pre-formulation study

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dc.creatorMaria Betânia de Freitas-Marques
dc.creatorOsmar Patrício Almeida
dc.creatorFlávia Lidiane Oliveira da Silva
dc.creatorBárbara Caroline Rodrigues Araújo
dc.creatorJosé Domingos Ardison
dc.creatorRita de Cássia de Oliveira
dc.creatorWagner da Nova Mussel
dc.creatorMaria Irene Yolshida
dc.creatorGuilherme Carneiro
dc.date.accessioned2025-09-04T19:06:37Z
dc.date.accessioned2025-09-09T00:50:09Z
dc.date.available2025-09-04T19:06:37Z
dc.date.issued2023
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doi10.1590/s2175-97902023e21460
dc.identifier.issn21759790
dc.identifier.urihttps://hdl.handle.net/1843/84879
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.rightsAcesso Aberto
dc.subjectArgila
dc.subject.otherMineral de argila rosa
dc.subject.otherFases de ferro
dc.subject.otherComportamento térmico
dc.subject.otherTecnologia de pó
dc.subject.otherEstabilidade de estado sólido
dc.subject.otherEstudo cinético
dc.titleSolid-state properties of pink clay from Jequitinhonha valley in Brazil for pre-formulation study
dc.typeArtigo de periódico
local.citation.epage13
local.citation.spage1
local.citation.volume59
local.description.resumoClay minerals are still widely used in pharmaceutical products for human health and cosmetic purposes. Pre-formulation studies were conducted to identify solid-state properties of pink clay, a sample from Diamantina, Brazil. Among the solid properties to be analyzed, we have selected type identification, iron phases, crystallinity, powder flow characteristics, thermal behavior, and non-isothermal phase transition kinetics. The pink clay is composed of (1:1) clay type and kaolinite as the main component. The Mössbauer spectrum of pink clay shows Fe3+(α-Fe2O3) hematite, Fe2+, and Fe3+ with large Δ/2ξq of about 2.80 and 2.69 mm.s-1 respectively, related to iron silicates, most likely pyroxene, and a superparamagnetic Fe3+. Pink clay exhibits poor flow properties. The thermal behavior indicates a phase-transition between 400 - 600 ºC associated with the dehydroxylation of the pink clay system requiring ~300 kJ mol-1, being constant until the process reaches a conversion of ~50% when the energy is enhanced to ~530 kJ mol-1, concluding the whole dehydroxylation process (α=80%). Solid-state properties and characteristics found for the pink clay must be considered for the proper design of formulations. This type of clay shows unique pharmaceutical properties that can be favorably exploited by the cosmetic industry.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bjps/a/4cxzmxHtfPSQrMyyfG4GdND/?format=html&lang=en

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