Influence of image reconstruction protocols on the image quality of a small animal PET scanner using 18F and 11C

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dc.creatorJoão Vitor do Carmo Barbosa
dc.creatorRodrigo Modesto Gadelha Gontijo
dc.creatorGuilherme Cavalcante de Albuquerque Souza
dc.creatorBruno Melo Mendes
dc.creatorJuliana Batista da Silva
dc.creatorMarcelo Mamede
dc.creatorAndréa Vidal Ferreira
dc.date.accessioned2023-08-02T20:53:13Z
dc.date.accessioned2025-09-08T23:07:56Z
dc.date.available2023-08-02T20:53:13Z
dc.date.issued2021-09-20
dc.format.mimetypepdf
dc.identifier.doi10.15392/bjrs.v9i3.1734
dc.identifier.issn23190612
dc.identifier.urihttps://hdl.handle.net/1843/57386
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Radiation Sciences
dc.rightsAcesso Aberto
dc.subjectTomografia por Emissão de Pósitrons
dc.subjectDiagnóstico por Imagem
dc.subject.otherSmall Animal PET
dc.subject.otherImage Quality
dc.subject.otherNEMA NU 4-2008
dc.titleInfluence of image reconstruction protocols on the image quality of a small animal PET scanner using 18F and 11C
dc.typeArtigo de periódico
local.citation.epage19
local.citation.issue3
local.citation.spage01
local.citation.volume9
local.description.resumoThe small animal positron emission tomography (PET) scanner from Molecular Imaging Laboratory (LIM/CDTN) is dedicated to pre-clinical studies on new 18F and 11C-based radiopharmaceuticals and to the development of novel applications for traditional radiopharmaceuticals. Quality control tests recommended by the NEMA publication NU 4-2008 are routinely carried out to ensure the proper performance of the PET scanner. The aim of this work was to evaluate the influence of image reconstruction protocols on the image quality, accuracy of attenuation and scatter correction parameters for 18F and 11C PET images. 18F-FDG and 11C-PK1122 PET images of the image quality phantom were acquired and then reconstructed using different reconstruction protocols varying algorithms (FBP, MLEM-3D, OSEM-3D), resolution mode (high/standard) and number of iterations (10 to 150). Uniformity, spill-over ratio (SOR) and recovery coefficient (RC) tests were performed for each reconstructed image according to NEMA NU 4-2008. FBP based protocol generated noisier images compared to iterative algorithms (MLEM-3D or OSEM-3D) based protocols. The increase in the number of iterations resulted in higher standard deviation of the analyzed parameters for all images. MLEM-3D and OSEM-3D based protocols generates similar results when the number of iterations and resolution mode were identical. SOR and RC mean values remained stable when the number of iterations ranged from 40 to 150. This study allowed the evaluation of different image reconstruction protocols on important parameters of 18F and 11C PET image quality. Additionally, standard protocols to be adopted in LIM/CDTN for 18F and 11C images reconstruction in preclinical studies were defined.
local.identifier.orcid0000-0001-6479-3087
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.initialsUFMG
local.url.externahttps://bjrs.org.br/revista/index.php/REVISTA/article/view/1734

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