Towards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment

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dc.creatorRosiana Estéfane Silva
dc.creatorJanaína Pina de Carvalho
dc.creatorDario Ramalho Brock
dc.creatorMaria Camilo Ribeiro de Senna
dc.creatorHugo Silva Assis Moreira
dc.creatorAna Lúcia Teles Rabello
dc.creatorErika Fernandes Cota
dc.creatorGlaucia Fernandes Cota
dc.date.accessioned2024-11-27T23:56:21Z
dc.date.accessioned2025-09-09T00:45:35Z
dc.date.available2024-11-27T23:56:21Z
dc.date.issued2017-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.format.mimetypepdf
dc.identifier.doi10.1590/0074-027601700125
dc.identifier.issn0074-0276
dc.identifier.urihttps://hdl.handle.net/1843/78337
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMemorias do Instituto Oswaldo Cruz
dc.rightsAcesso Aberto
dc.subjectLeishmaniose Cutânea
dc.subjectTerapia
dc.subjectAntimoniato de Meglumina
dc.subjectEstudo de Validação
dc.titleTowards a standard protocol for antimony intralesional infiltration technique for cutaneous leishmaniasis treatment
dc.typeArtigo de periódico
local.citation.epage79
local.citation.issue2
local.citation.spage71
local.citation.volume113
local.description.resumoBACKGROUND: Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES: This study aims to validate the standard operational procedure (SOP) for the intralesional infiltration of MA for CL therapy as the first step before the assessment of efficacy and safety related to the procedure. METHODS: The SOP was created based on 21 trials retrieved from the literature, direct monitoring of the procedure and consultation with experts. This script was submitted to a formal computer-aided inspection to identify readability, clarity, omission, redundancy and unnecessary information (content validation). For criterion and construct validations, the influence of critical condition changes (compliance with the instructions and professional experience) on outcome conformity (saturation status achievement), tolerability (pain referred) and safety (bleeding) were assessed. FINDINGS: The median procedure length was 12 minutes and in 72% of them, patients classified the pain as mild. The bleeding was also classified as mild in 96.6% of the procedures. Full compliance with the SOP was observed in 66% of infiltrations. Despite this, in 100% of the inspected procedures, lesion saturation was observed at the end of infiltration, which means that it tolerates some degree of modification in its execution (robustness) without prejudice to the result. CONCLUSIONS: The procedure is reproducible and can be used by professionals without previous training with high success and safety rates.
local.publisher.countryBrasil
local.publisher.departmentMEDICINA - FACULDADE DE MEDICINA
local.publisher.initialsUFMG
local.url.externahttps://scielo.br/j/mioc/a/STLNJQcBcr4JYLLJ3ymDhFc/?lang=en#

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