Reduced chromatin acetylation of malignant salivary gland tumors correlates with enhanced proliferation.

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dc.creatorVivian Petersen Wagner
dc.creatorManoela Domingues Martins
dc.creatorDouglas Magno Guimarães
dc.creatorArtur Cunha Vasconcelos
dc.creatorLuize Meurer
dc.creatorPablo Augustin Vargas
dc.creatorFelipe Paiva Fonseca
dc.creatorCristiane Helena Squarize
dc.creatorRogério Moraes Castilho
dc.date.accessioned2023-09-22T20:15:23Z
dc.date.accessioned2025-09-09T01:27:02Z
dc.date.available2023-09-22T20:15:23Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1111/jop.12557
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/58869
dc.languagepor
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal oral pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectAcetylation
dc.subjectEpigenomics
dc.subjectNeoplasms
dc.subjectHistones
dc.subjectImmunohistochemistry
dc.subjectSalivary gland neoplasms
dc.titleReduced chromatin acetylation of malignant salivary gland tumors correlates with enhanced proliferation.
dc.typeArtigo de periódico
local.citation.epage797
local.citation.issue9
local.citation.spage792
local.citation.volume46
local.description.resumoBackground: Epigenetic changes refer to any heritable modification in gene expression independent of alterations in the DNA sequence. Currently, it is well established that epigenetics represents a crucial player for tumor development. Nevertheless, the epigenetic mechanisms involved in the development and progression of salivary gland tumors (SGTs) remain poorly understood. Methods: In this study, we analyzed the pattern of acetyl-histone H3 (lys9) expression in benign and malignant SGTs and further correlate our results with tumors' proliferative activity and clinical outcomes. We assembled tissue microarrays (TMAs) of 84 cases of SGTs and analyzed for acetyl-histone H3 (lys9) and Ki-67 using immunohistochemistry. The study comprised 42 benign and 42 malignant SGTs. Results: All cases included in this study were positive to acetyl-H3 (lys9). We observed that malignant SGTs were hypoacetylated compared with benign (P = 0.04). Moreover, acetyl-H3 (lys9) expression was inversely correlated with Ki67 (**P = 0.02). Conclusion: This study provides the first insight regarding histone modifications in SGTs. Our results suggest that epigenetic mechanism, particularly hypoacetylation of histone H3 (lys9), might play a role in the behavior of salivary gland tumors. Also, our findings suggest that interfering with the acetylation pattern of tumor histones represents a potential novel therapeutic strategy for the treatment of SGTs
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12557

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