Derivatives of furanditerpenes from Pterodon genus: pharmacological studies disclose their potential as chronic pain relief in mice

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dc.creatorHumberto Moreira Spindola
dc.creatorRogério Grando
dc.creatorMariana Cecchetto Figueiredo
dc.creatorRosanna Tarkany Basting
dc.creatorNúbia de Cássia Almeida Queiroz
dc.creatorÂngelo de Fátima
dc.creatorJoão Ernesto de Carvalho
dc.creatorZaijie Jim Wang
dc.creatorMary Ann Foglio
dc.date.accessioned2024-08-02T21:34:51Z
dc.date.accessioned2025-09-09T01:07:40Z
dc.date.available2024-08-02T21:34:51Z
dc.date.issued2017
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2017.03.030
dc.identifier.issn0014-2999
dc.identifier.urihttps://hdl.handle.net/1843/72495
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Pharmacology
dc.rightsAcesso Restrito
dc.subjectBioquímica
dc.subjectQuímica
dc.subjectDiterpenos
dc.subjectPlantas medicinais
dc.subjectAnalgésicos
dc.subjectDor intratável
dc.subject.otherAnalgesics
dc.subject.otherFuranditerpenes
dc.subject.otherBrazilian flora
dc.subject.otherAnti-inflammatory
dc.titleDerivatives of furanditerpenes from Pterodon genus: pharmacological studies disclose their potential as chronic pain relief in mice
dc.typeArtigo de periódico
local.citation.epage77
local.citation.spage68
local.citation.volume804
local.description.resumoPterodon genus fruits are commercially available at the Brazilian medicinal market used in folk medicine due to their anti-inflammatory, analgesic, and anti-rheumatic effects. Previous studies demonstrated that furanditerpenes possessing vouacapan skeleton, isolated from Pterodon genus, possess expressive antinociceptive activities, with promising moiety for the development of new analgesic products. The antinociceptive properties of compounds 6α,7β-6α-hidroxivouacapan-7β-17β-lactone (HVL) and 6α-oxovouacapan-7β-17β-lactone (OVL), semi-synthetic analogues of furanditerpenes previously reported as analgesic agents were evaluated on animal experimental models (Spindola et al., 2010, 2011). The chemical-induced pain methods used in the present work, demonstrated for the first time that both compounds HVL and OVL have potential as important templates for the development of chronic pain control drugs. The main findings of this work were that both compounds were: effective in the writhing test; reduced paw edema in the carrageenan test; effective in the inflammatory phase of the formalin test corroborating their activity against inflammatory pain conditions; effective on reducing pain through the stimulation of vanilloid receptors sensible to capsaicin (an important pathway for chronic pain maintenance); reduced the pain stimulus caused by PGE2 injection (a pathway involved in chronic pain hypersensitivity); effective on decreasing mechanical allodynia in the CFA-model, demonstrating their potential use against chronic pain disorders.
local.identifier.orcidhttps://orcid.org/0009-0004-8142-3650
local.identifier.orcidhttps://orcid.org/0000-0001-7513-102X
local.identifier.orcidhttps://orcid.org/0000-0001-7231-4680
local.identifier.orcidhttps://orcid.org/0000-0003-1510-5684
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0002-3496-4655
local.identifier.orcidhttps://orcid.org/0009-0008-5478-0977
local.publisher.countryBrasil
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0014299917302030?via%3Dihub

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