Peak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study

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dc.creatorAna Karine Vieira
dc.creatorCristina Gonçalves Alvim
dc.creatorClara Polito Braga
dc.creatorRicardo Reis Dinardi
dc.creatorMarcos Vinícius Domingues Borba
dc.creatorRicardo Manoel Oliveira Rodrigues
dc.creatorCássio da Cunha Ibiapina
dc.date.accessioned2025-03-06T21:42:05Z
dc.date.accessioned2025-09-08T23:08:40Z
dc.date.available2025-03-06T21:42:05Z
dc.date.issued2023-09
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1806-9282.20210819
dc.identifier.issn1806-9282
dc.identifier.urihttps://hdl.handle.net/1843/80549
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Associação Médica Brasileira
dc.rightsAcesso Aberto
dc.subjectAnemia Falciforme
dc.subjectRinomanometria
dc.subjectHipóxia
dc.subjectHemoglobinopatias
dc.subjectRinometria Acústica
dc.subject.otherSickle cell disease
dc.subject.otherHemoglobinopathies
dc.subject.otherRhinomanometry
dc.subject.otherAcoustic rhinometry
dc.subject.otherHypoxemia
dc.titlePeak nasal inspiratory flow in children and adolescents with sickle cell disease: a case-control study
dc.typeArtigo de periódico
local.citation.epage4
local.citation.issue10
local.citation.spage1
local.citation.volume69
local.description.resumoOBJECTIVE: Sickle cell disease is the most frequent of the hereditary hemoglobinopathies and it presents multisystemic effects. A manifestation that is commonly found in sickle cell disease is upper airway obstruction, particularly adenotonsillar hypertrophy. This study aims to evaluate the peak nasal inspiratory flow measurements of children and adolescents with sickle cell disease. METHODS: This is a case-control study on children aged between 8 and 15 years who were diagnosed with sickle cell disease. Peak nasal inspiratory flow measurements were obtained from patients. RESULTS: A total of 279 patients were enrolled in this study, with 93 in the case group and 186 in the control group. The case group had an 82.83% chance of having lower peak nasal inspiratory flow values than the control group. In the case group, 75% of the peak nasal inspiratory flow values were in the lower standards, whereas in the control group, only 25% were in the lower standards. CONCLUSION: This study showed a high prevalence of reduced peak nasal inspiratory flow values in children with sickle cell disease and could certainly be incorporated into the day-to-day clinical evaluation of patients as a screening instrument.
local.identifier.orcidhttps://orcid.org/0000-0002-8289-8461
local.identifier.orcidhttps://orcid.org/0000-0002-5234-5479
local.identifier.orcidhttps://orcid.org/0000-0002-3279-4891
local.identifier.orcidhttps://orcid.org/0000-0002-7457-2939
local.identifier.orcidhttps://orcid.org/0000-0002-6761-5654
local.identifier.orcidhttps://orcid.org/0000-0002-3989-4350
local.identifier.orcidhttps://orcid.org/0000-0003-3607-8857
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/ramb/a/6Y5CGk3Qssss5M5SyvWZtMp/?format=pdf&lang=en

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