Cigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis

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dc.creatorPaula Barbim Donate
dc.creatorRene D. Oliveira
dc.creatorGeraldo Aleixo Passos
dc.creatorJosé Carlos Alves-Filho
dc.creatorThiago Mattar. Cunha
dc.creatorPaulo Louzada-Junior
dc.creatorFoo Yew Liew
dc.creatorFernando de Queiroz Cunha
dc.creatorKalil Alves de Lima
dc.creatorRaphael Sanches Peres
dc.creatorFausto Almeida
dc.creatorSandra Yasuyo Fukada Alves
dc.creatorTarcília Aparecida da Silva
dc.creatorDaniele Carvalho Bernardo Nascimento
dc.creatorNerry Tatiana Cecilio
dc.creatorJhimmy Talbot
dc.date.accessioned2025-05-05T22:14:44Z
dc.date.accessioned2025-09-09T00:55:14Z
dc.date.available2025-05-05T22:14:44Z
dc.date.issued2020-12-28
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1073/pnas.2017120118
dc.identifier.issn1091-6490
dc.identifier.urihttps://hdl.handle.net/1843/82039
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
dc.rightsAcesso Aberto
dc.subjectTh17 cells
dc.subjectExosomes
dc.subjectOsteogenesis
dc.subjectArthritis, rheumatoid
dc.subjectCyclooxygenase 2
dc.subjectOsteoclasts
dc.subjectTobacco use disorder
dc.subject.otherTh17
dc.subject.otherCigarette smoke
dc.subject.otherExosomes
dc.subject.otherOsteoclastogenesis
dc.subject.otherRheumatoid arthritis
dc.titleCigarette smoke induces miR-132 in Th17 cells that enhance osteoclastogenesis in inflammatory arthritis
dc.typeArtigo de periódico
local.citation.epagee2017120125
local.citation.issue1
local.citation.spagee2017120118
local.citation.volume118
local.description.resumoRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint destruction and severe morbidity. Cigarette smoking (CS) can exacerbate the incidence and severity of RA. Although Th17 cells and the Aryl hydrocarbon receptor (AhR) have been implicated, the mechanism by which CS induces RA development remains unclear. Here, using transcriptomic analysis, we show that microRNA-132 is specifically induced in Th17 cells in the presence of either AhR agonist or CS-enriched medium. miRNA-132 thus induced is packaged into extracellular vesicles produced by Th17 and acts as a proinflammatory mediator increasing osteoclastogenesis through the down-regulation of COX2. In vivo, articular knockdown of miR-132 in murine arthritis models reduces the number of osteoclasts in the joints. Clinically, RA patients express higher levels of miR-132 than do healthy individuals. This increase is further elevated by cigarette smoking. Together, these results reveal a hitherto unrecognized mechanism by which CS could exacerbate RA and further advance understanding of the impact of environmental factors on the pathogenesis of chronic inflammatory diseases.
local.identifier.orcidhttps://orcid.org/0000-0002-9918-8714
local.identifier.orcidhttps://orcid.org/0000-0002-4408-140X
local.identifier.orcidhttps://orcid.org/0000-0001-8422-8894
local.identifier.orcidhttps://orcid.org/0000-0002-7855-3700
local.identifier.orcidhttps://orcid.org/0000-0003-2585-3870
local.identifier.orcidhttps://orcid.org/0000-0003-4755-1670
local.identifier.orcidhttps://orcid.org/0000-0002-9149-168X
local.identifier.orcidhttps://orcid.org/0000-0002-0417-779X
local.identifier.orcidhttps://orcid.org/0000-0002-6589-4784
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0002-0620-339X
local.identifier.orcidhttps://orcid.org/0000-0001-5465-5238
local.identifier.orcidhttps://orcid.org/0000-0002-0347-5074
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://www.pnas.org/doi/10.1073/pnas.2017120118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

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