V brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cells

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dc.creatorWilson de Melocruvinel
dc.creatorFabiano de Almeida Brito
dc.creatorFernanda Bull Flumian
dc.creatorGlaucielen Gomes da Silva
dc.creatorJozelia Rêgo
dc.creatorLisiane Maria Ericoni Dos Anjos
dc.creatorNatasha Slhessarenko
dc.creatorSandra Gofinet Pasoto
dc.creatorSuzane Pretti Figueiredo Neves
dc.creatorValéria Valim
dc.creatorWilton Silva Dos Santos
dc.creatorLuis Eduardo Coelho Andrade
dc.creatorPaulo Luiz Carvalho Francescantonio
dc.creatorCarlos Alberto Von Mühlen
dc.creatorAlessandra Dellavance
dc.creatorAntônio Carlos Ximenes
dc.creatorCarlos David Bichara
dc.creatorCleonice Bueno
dc.creatorCristóvão Luis Pitangueira Mangueira
dc.creatorEloísa Bonfá
dc.date.accessioned2023-06-12T19:58:38Z
dc.date.accessioned2025-09-08T23:24:15Z
dc.date.available2023-06-12T19:58:38Z
dc.date.issued2019
dc.format.mimetypepdf
dc.identifier.doi10.1186/s42358-019-0069-5
dc.identifier.issn25233106
dc.identifier.urihttps://hdl.handle.net/1843/54836
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAdvances in Rheumatology
dc.rightsAcesso Aberto
dc.subjectAutoanticorpos
dc.subjectCélulas Hep G2
dc.subjectAnticorpos Antinucleares
dc.subjectTécnica Indireta de Fluorescência para Anticorpo
dc.subjectPadrões de Referência
dc.subject.otherANA
dc.subject.otherAutoantibodies
dc.subject.otherHEp-2 cells
dc.subject.otherAntinuclear antibodies
dc.subject.otherIndirect immunofluorescence
dc.subject.otherStandardization
dc.titleV brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cells
dc.typeArtigo de periódico
local.citation.epage11
local.citation.issue29
local.citation.spage1
local.citation.volume59
local.description.resumoBackground: The V Brazilian Consensus for determination of autoantibodies against cellular constituents on HEp-2 cells, held in Brasilia (DF, Brazil) on August 27, 2016, discussed the harmonization between the Brazilian Consensus on ANA (BCA) guidelines and the International Consensus on ANA Patterns (ICAP) recommendations (www.anapatterns.org). Initial guidelines were formulated by the group of Brazilian experts with the purpose of guiding and enabling Brazilian clinical laboratories to adopt recommendations and to provide a common standard for national and international consensuses. Mainbody: Twenty Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of the country participated in the meeting. Three main topics were discussed, namely the harmonization between the BCA guidelines and latest recommendations of the ICAP initiative, the adjustment of the terminology and report on HEp-2 patterns, and a reassessment of quality assurance parameters. For the three topics, our aim was to establish specific guidelines. All recommendations were based on consensus among participants. There was concrete progress in the adjustment of the BCA guidelines to match the ICAP guidelines. To a certain extent, this derives from the fact that ICAP recommendations were largely based on the algorithm and recommendations of the IV Brazilian ANA Consensus, as consistently recognized in the ICAP publications and presentations. However, although there is great overlap between the two Consensuses, there are some point divergences. These specific items were individually and extensively discussed, and it was acknowledged that in several points ICAP improved recommendations previously issued by the Brazilian ANA Consensus and these changes were readily implemented. Regarding some specific topics, the BCA panel of experts felt that the previously issued recommendations remained relevant and possibly will require further discussion with ICAP. The term anti-cell antibodies was adopted as the recommended designation, recognizing that the assay addresses antibodies against antigens in the nucleus and in other cell compartments. However, the acronym ANA HEp-2 was maintained due to historical and regulatory reasons. It was also signalized that the latest trend in ICAP is to adopt the term Indirect Immunofluorescent Assay on HEp-2 cell substrate (HEp-2 IIFA). In addition, the quality assurance strategies previously presented were ratified and emphasized.Conclusion: The V BCA edition was successful in establishing an overall harmonization with the ICAP recommendations for interpretation of the HEp-2 IIFA test, pinpointing the perspectives in filling the remaining gaps between both initiatives.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-019-0069-5

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