Oral melanoacanthoma: clinicopathological and immunohistochemical features of a case series and a scoping review

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dc.creatorThalita Soares Tavares
dc.creatorSandra Beatriz Chaves Tarquínio
dc.creatorPatrícia Carlos Caldeira
dc.creatorAdriana Aparecida Silva da Costa
dc.creatorFelipe da Mata Camargos
dc.creatorRicardo Santiago Gomez
dc.creatorCassiano Francisco Weege Nonaka
dc.creatorPollianna Muniz Alves
dc.creatorElismauro Francisco Mendonça
dc.creatorSebastião Silvério Sousa-Neto
dc.creatorAna Carolina Uchoa Vasconcelos
dc.date.accessioned2024-09-13T00:26:19Z
dc.date.accessioned2025-09-09T00:08:16Z
dc.date.available2024-09-13T00:26:19Z
dc.date.issued2023
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1111/jop.13495
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/1843/76412
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectMelanocytes
dc.subjectMouth mucosa
dc.subjectPigmentation disorders
dc.subjectT-lymphocytes
dc.subjectBiopsy
dc.subjectElectronic health records
dc.subjectImmunohistochemistry
dc.subject.otherX
dc.titleOral melanoacanthoma: clinicopathological and immunohistochemical features of a case series and a scoping review
dc.typeArtigo de periódico
local.citation.epage1020
local.citation.issueJournal of Oral Pathology & Medicine assunto Melanocytes fao clínica
local.citation.spage1013
local.citation.volume52
local.description.resumoBackground: This study presents a case series and scoping review of oral melanoacanthoma to examine its clinical, histopathological, and immunohistochemical characteristics. Methods: Nine cases of oral melanoacanthoma were included in the case series. Clinical data were collected from biopsy charts. Hematoxylin-eosin and immunohistochemistry for TRP2, CD3, and CD20 were done. For the scoping review, MEDLINE/PubMed, Web of Science, EMBASE, and Scopus were searched. Results: Case series: The mean age was 46.8 years (female-to-male ratio 2:1). Lesion's mean size was 11.0 mm (±9.3). Lesions were mainly macular (77.8%) with brown or black coloration (88.9%) and often affected multiple sites (44.4%). The evolution time ranged from 15 days to 96 months. Lesions commonly showed epithelial acanthosis (66.7%), spongiosis (55.6%), exocytosis (77.8%), melanin incontinence (88.9%), and inflammatory infiltrate in the lamina propria (77.8%), from which all showed lymphocytes. TRP2-positive melanocytes were identified in the basal and spinous layer of all cases, and in the superficial layer of three cases. CD3-positive cells predominate over the CD20-positive. Scoping review: 85 cases of oral melanoacanthoma were retrieved from 55 studies. Patients were primarily female (female-to-male ratio 2.2:1), black-skinned (64.1%), with a mean age of 36.13 (± 17.24). Lesions were flat (81.9%), often brown (62.4%). Buccal mucosa was the preferred site (32.9%), followed by multiple sites (28.2%). Conclusion: Oral melanoacanthoma mainly affects women across a wide age range, with lesions commonly appearing as brown/black macules, particularly on the buccal mucosa. TRP2-positive melanocytes and T-lymphocytes were consistently found and could participate in oral melanoacanthoma pathogenesis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.13495

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