Synthesis and evaluation of platinum complexes with potential antitumor activity

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dc.creatorRachel Lima Marcelino Freire
dc.creatorMaria Betânia de Freitas Marques
dc.creatorElaine Maria de Souza-Fagundes
dc.creatorRenata Barbosa de Oliveira
dc.creatorRicardo José Alves
dc.date.accessioned2022-03-29T21:07:31Z
dc.date.accessioned2025-09-08T23:25:21Z
dc.date.available2022-03-29T21:07:31Z
dc.date.issued2017
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.format.mimetypepdf
dc.identifier.doi10.1590/s2175-97902017000115235
dc.identifier.issn19848250
dc.identifier.urihttps://hdl.handle.net/1843/40580
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.rightsAcesso Aberto
dc.subjectComplexos de platina
dc.subjectAtividade citotóxica
dc.subject.otherCytotoxic activity
dc.subject.otherPlatinum complexes
dc.subject.otherEhrlich solid tumor activity
dc.titleSynthesis and evaluation of platinum complexes with potential antitumor activity
dc.typeArtigo de periódico
local.citation.epage7
local.citation.issue1
local.citation.spage1
local.citation.volume53
local.description.resumoA novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results.
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOS
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bjps/a/phzPyCQnkc5yWpyyHtrPcky/?lang=en

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