Sympathetic autonomic denervation in heart failure: comparison of chagas? heart disease with other dilated cardiomyopathy

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dc.creatorViviane Parisotto Marino
dc.creatorSandra Monetti Dumont
dc.creatorLuciene Das Graças Mota
dc.creatorDaniela Braga
dc.creatorStephanie Saliba de Freitas
dc.creatorMaria da Consolação Vieira Moreira
dc.date.accessioned2024-01-12T21:13:45Z
dc.date.accessioned2025-09-09T00:26:57Z
dc.date.available2024-01-12T21:13:45Z
dc.date.issued2017
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.5935/abc.20180124
dc.identifier.issn23049693
dc.identifier.urihttps://hdl.handle.net/1843/62754
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.rightsAcesso Aberto
dc.subjectHeart Failure
dc.subjectPrimary Dysautonomias
dc.subjectChagas Cardiomyopathy
dc.subjectGated Blood-Pool Imaging
dc.subject3-Iodobenzylguanidine
dc.subject.otherHeart Failure
dc.subject.otherPrimary Dysautonomias
dc.subject.otherChagas Cardiomyopathy
dc.subject.otherMyocardial/radionuclide imaging
dc.subject.otherI-metaiodobenzylguanidine
dc.titleSympathetic autonomic denervation in heart failure: comparison of chagas? heart disease with other dilated cardiomyopathy
dc.typeArtigo de periódico
local.citation.epage190
local.citation.issue2
local.citation.spage182
local.citation.volume111
local.description.resumoBackground: Heart failure (HF) is a severe public health problem because of its high morbidity and mortality and elevated costs, thus requiring better understanding of its course. In its complex and multifactorial pathogenesis, sympathetic hyperactivity plays a relevant role. Considering that sympathetic dysfunction is already present in the initial phases of chronic Chagas cardiomyopathy (CCC) and frequently associated with a worse prognosis, we assumed it could be more severe in CCC than in cardiomyopathies of other etiologies (non-CCC).Objectives: To assess the cardiac sympathetic dysfunction (123I-MIBG) of HF, comparing individuals with CCC to those with non-CCC, using heart transplant (HT) patients as denervated heart parameters.Methods: We assessed 76 patients with functional class II-VI HF, being 25 CCC (17 men), 25 non-CCC (14 men) and 26 HT (20 men), by use of cardiac 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy, estimating the early and late heart-to-mediastinum ratio (HMR) of 123I-MIBG uptake and cardiac washout (WO%). The 5% significance level was adopted in the statistical analysis.Results: The early and late HMR values were 1.73 ± 0.24 and 1.58 ± 0.27, respectively, in CCC, and 1.62 ± 0.21 and 1.44 ± 0.16 in non-CCC (p = NS), being, however, higher in HT patients (p < 0.001). The WO% values were 41.65 ± 21.4 (CCC), 47.37 ± 14.19% (non-CCC) and 43.29 ± 23.02 (HT), p = 0.057. The late HMR values showed a positive weak correlation with left ventricular ejection fraction (LVEF) in CCC and non-CCC (r = 0.42 and p = 0.045; and r = 0.49 and p = 0.015, respectively).Conclusion: Sympathetic hyperactivity (123I-MIBG) was evidenced in patients with class II-IV HF, LVEF < 45%, independently of the HF etiology, as compared to HT patients. (Arq Bras Cardiol. 2018; 111(2):182-190
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEM
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.5935/abc.20180124

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