Photobiomodulation of mesenchymal stem cells encapsulated in an injectable rhbmp4-loaded hydrogel directs hard tissue bioengineering

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dc.creatorIvana Márcia Alves Diniz
dc.creatorMari Cleide Sogayar
dc.creatorMárcia Martins Marques
dc.creatorAna Cláudia Carreira
dc.creatorCarla Renata Sipert
dc.creatorCindi Mie Uehara
dc.creatorMaria Stella Nunes Moreira
dc.creatorLaila Freire
dc.creatorCibele Pelissari
dc.creatorPatrícia Kossugue
dc.creatorDaniele Ribeiro de Araújo
dc.date.accessioned2022-12-16T15:01:19Z
dc.date.accessioned2025-09-09T00:02:53Z
dc.date.available2022-12-16T15:01:19Z
dc.date.issued2017
dc.identifier.doihttps://doi.org/10.1002/jcp.26309
dc.identifier.issn00219541
dc.identifier.urihttps://hdl.handle.net/1843/48142
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Cellular Physiology
dc.rightsAcesso Restrito
dc.subjectHydrogels
dc.subjectLow-level light therapy
dc.subjectMesenchymal stem cells
dc.subjectPoloxamer
dc.subject.otherhydrogel
dc.titlePhotobiomodulation of mesenchymal stem cells encapsulated in an injectable rhbmp4-loaded hydrogel directs hard tissue bioengineering
dc.typeArtigo de periódico
local.citation.epage4918
local.citation.issue6
local.citation.spage4907
local.citation.volume233
local.description.resumoPhotobiomodulation (PBM) therapy displays relevant properties for tissue healing and regeneration, which may be of interest for the tissue engineering field. Here, we show that PBM is able to improve cell survival and to interact with recombinant human Bone Morphogenetic Protein 4 (rhBMP4) to direct and accelerate odonto/osteogenic differentiation of dental derived mesenchymal stem cells (MSCs). MSCs were encapsulated in an injectable and thermo-responsive cell carrier (Pluronic® F-127) loaded with rhBMP4 and then photoactivated. PBM improved MSCs self-renewal and survival upon encapsulation in the Pluronic® F-127. In the presence of rhBMP4, cell odonto/osteogenic differentiation was premature and markedly improved in the photoactivated MSCs. An in vivo calvarial critical sized defect model demonstrated significant increase in bone formation after PBM treatment. Finally, a balance in the reactive oxygen species levels may be related to the favorable results of PBM and rhBMP4 association. PBM may act in synergism with rhBMP4 and is a promise candidate to direct and accelerate hard tissue bioengineering.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1002/jcp.26309

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