Immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of the ampulla of vater

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dc.creatorJoão Paulo Lemosda Silveira Santos
dc.creatorCarla Jorge Machado
dc.creatorEduardo Paulino Junior
dc.creatorJoão Bernardo Sancio Rocha Rodrigues
dc.creatorPaula Teixeira Vidigal
dc.creatorVivian Resende
dc.date.accessioned2023-06-19T20:40:05Z
dc.date.accessioned2025-09-09T01:13:15Z
dc.date.available2023-06-19T20:40:05Z
dc.date.issued2018-05-07
dc.format.mimetypepdf
dc.identifier.doihttps://10.1007/s11605-018-3797-7
dc.identifier.issn1091255X
dc.identifier.urihttps://hdl.handle.net/1843/55133
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Gastrointestinal Surgery
dc.rightsAcesso Aberto
dc.subjectAmpola Hepatopancreática
dc.subjectAdenocarcinoma Sebáceo
dc.subjectImuno-Histoquímica
dc.subjectSurvival
dc.subject.otherAmpulla of Vater
dc.subject.otherAdenocarcinoma
dc.subject.otherImmunohistochemistry
dc.subject.otherSurvival
dc.titleImmunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of the ampulla of vater
dc.typeArtigo de periódico
local.citation.epage8
local.citation.spage1
local.citation.volume1
local.description.resumoObjectives To investigate immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of ampulla of Vater and identify clinicopathological characteristics associated with the histological types and patient survival. Methods Immunohistochemical markers included MUC1, MUC2, MUC5AC, CDX2, CK7, and CK20. The data were analyzed by univariate and multivariate methods. The two-step cluster method was used to determine the best immunohistochemical markers to discriminate the intestinal from the pancreatobiliary type. Results This study identified 9 (33.3%) intestinal and 21 (66.7%) pancreatobiliary tumors. CK7 and CDX2 achieved the highest value (= 1) as predictor markers, while CK20, MUC1, and MUC2 showed degrees of importance equal to 0.77, 0.71, and 0.68, respectively. MUC5AC did not reach 0.50 of importance. In the univariate analysis, lymph node involvement, staging (TNM), and angiolymphatic and perineural invasions were associated with histological types. The independent clinicopathological variable in the multivariate model to predict the histological type was angiolymphatic invasion (p = 0.005), OR = 17 (95% CI 2.33 to 123.83). The final model showed positive nodes (N1) associated with shorter survival (HR = 9.5; p = 0.006). Overallsurvival at 12, 36, and 60 months was 88.5, 67.0, and 47.6%, respectively. Conclusions CDX2 and CK7 were the immunohistochemical markers that best discriminated the intestinal from the pancreatobiliary type. Lymph node involvement had a high impact on survival and proved to be more frequent in the pancreatobiliary type.
local.identifier.orcidhttps://orcid.org/0000-0001-6157-6511
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL
local.publisher.departmentMED - DEPARTAMENTO DE CIRURGIA
local.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11605-018-3797-7

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