Convergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves

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dc.creatorVanessa Bueris
dc.creatorFábio P. Sellera
dc.creatorBruna Fuga
dc.creatorElder Sano
dc.creatorMarcelo Pires Nogueira de Carvalho
dc.creatorSamuel Campanelli Freitas Couto
dc.creatorQuezia Moura
dc.creatorNilton Lincopan
dc.date.accessioned2024-05-29T18:15:43Z
dc.date.accessioned2025-09-09T00:38:39Z
dc.date.available2024-05-29T18:15:43Z
dc.date.issued2022
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.identifier.doihttp://dx.doi.org/10.1038/s41598-022-09598-8
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1843/68769
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofScientific Reports
dc.rightsAcesso Aberto
dc.subjectEnterobacteriaceae
dc.subjectOrganização Mundial da Saúde
dc.subjectBivalves
dc.subjectIntoxicação por frutos do mar
dc.subject.otherEnterobacterales
dc.subject.otherWHO
dc.subject.otherMarine bivalves
dc.subject.otherSeafood
dc.titleConvergence of virulence and resistance in international clones of WHO critical priority enterobacterales isolated from Marine Bivalves
dc.typeArtigo de periódico
local.citation.volume12
local.description.resumoThe global spread of critical-priority antimicrobial-resistant Enterobacterales by food is a public health problem. Wild-caught seafood are broadly consumed worldwide, but exposure to land-based pollution can favor their contamination by clinically relevant antimicrobial-resistant bacteria. As part of the Grand Challenges Explorations: New Approaches to Characterize the Global Burden of Antimicrobial Resistance Program, we performed genomic surveillance and cell culture-based virulence investigation of WHO critical priority Enterobacterales isolated from marine bivalves collected in the Atlantic Coast of South America. Broad-spectrum cephalosporin-resistant Klebsiella pneumoniae and Escherichia coli isolates were recovered from eight distinct geographical locations. These strains harbored blaCTX-M-type or blaCMY-type genes. Most of the surveyed genomes confirmed the convergence of wide virulome and resistome (i.e., antimicrobials, heavy metals, biocides, and pesticides resistance). We identified strains belonging to the international high-risk clones K. pneumoniae ST307 and E. coli ST131 carrying important virulence genes, whereas in vitro experiments confirmed the high virulence potential of these strains. Thermolabile and thermostable toxins were identified in some strains, and all of them were biofilm producers. These data point to an alarming presence of resistance and virulence genes in marine environments, which may favor horizontal gene transfer and the spread of these traits to other bacterial species.
local.identifier.orcidhttps://orcid.org/0000-0002-0210-8352
local.identifier.orcidhttps://orcid.org/0000-0002-3758-4148
local.identifier.orcidhttps://orcid.org/0000-0003-0161-5800
local.publisher.countryBrasil
local.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIA
local.publisher.initialsUFMG
local.url.externahttps://www.nature.com/articles/s41598-022-09598-8

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