Muscle strength and psychiatric symptoms influence health-related quality of life in patients with myasthenia gravis

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dc.creatorNayara Felicidade Tomazbraz
dc.creatorNatalia Pessoa Rocha
dc.creatorÉrica Leandro Marciano Vieira
dc.creatorIzabela Guimarães Barbosa
dc.creatorRodrigo Santiago Gomez
dc.creatorAdriana Maria Kakehasi
dc.creatorAntonio Lucio Teixeira
dc.date.accessioned2023-07-17T21:26:05Z
dc.date.accessioned2025-09-08T23:26:00Z
dc.date.available2023-07-17T21:26:05Z
dc.date.issued2018-01-05
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.jocn.2018.01.011
dc.identifier.issn09675868
dc.identifier.urihttps://hdl.handle.net/1843/56526
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Clinical Neuroscience
dc.rightsAcesso Restrito
dc.subjectMiastenia Gravis
dc.subjectQualidade de Vida
dc.subjectAnsiedade
dc.subjectDepressão
dc.subjectDebilidade Muscular
dc.subject.otherMyasthenia gravis
dc.subject.otherHealth-related quality of life
dc.subject.otherAnxiety
dc.subject.otherDepression
dc.subject.otherMuscle weakness
dc.titleMuscle strength and psychiatric symptoms influence health-related quality of life in patients with myasthenia gravis
dc.typeArtigo de periódico
local.citation.epage44
local.citation.spage41
local.citation.volume50
local.description.resumoMyasthenia gravis (MG) is a neuromuscular autoimmune disease characterized by skeletal muscle weakness which can impact motor function and, furthermore, produce negative impact on the health-related quality of life (HRQOL). Objective: To evaluate the predictors for HRQOL in patients with MG. Methods: Eighty patients were evaluated with the MG Foundation of America classification and the MG Composite scale. HRQOL was estimated by the MGQOL15, while anxious and depressive symptoms were evaluated with the Hospital Anxiety and Depression Scale (HAD). Results: The mean age of patients was 41.9 years with mean illness duration of 13.5 years. Almost half of the patients (43.75%) had significant anxiety and more than a quarter (27.50%) had depressive symptoms. Factors that influenced the HRQOL in MG were skeletal muscle weakness and anxiety and depressive symptoms (p < .001 in logistic regres sion model). Conclusion: Anxiety and depressive symptoms, besides motor symptoms, influence HRQOL inMG. Mental health must be a clinical focus in addition to the treatment of somatic symptoms during the course of MG.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE APARELHO LOCOMOTOR
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0967586817312274?via%3Dihub

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