Síndrome de Cushing subdiagnosticada em cão - relato de caso

Abstract

Cushing's Syndrome is an endocrinopathy caused by the chronic excess of glucocorticoid activity. The disease can present in its typical form, characterized by increased cortisol detected in classic diagnostic tests, or its atypical form, where there is excessive production of intermediate steroids, such as 17-hydroxyprogesterone (17-OHP), even with normal cortisol results. Recently, the term "subdiagnostic" has been used for these atypical cases. Diagnosis represents a challenge, requiring clinical interpretation and the performance of complementary tests to confirm the disease. The objective of this study is to report the case of a female Golden Retriever with clinical signs compatible with Cushing's, diagnosed through serum dosage of 17-OHP. The case discusses diagnostic difficulties and therapeutic management in patients with compatible clinical manifestations but inconclusive laboratory results, reinforcing the importance of a broad and individualized approach for the diagnosis and monitoring of the disease.