Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease

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dc.creatorJames Varni
dc.creatorRobert Shulman
dc.creatorMariella Self
dc.creatorShehzad Saeed
dc.creatorGeorge Zacur
dc.creatorAshish Patel
dc.creatorSamuel Nurko
dc.creatorDeborah Neigut
dc.creatorJames Franciosi
dc.creatorMiguel Saps
dc.creatorJolanda Denham
dc.creatorChelsea Vaughan Dark
dc.creatorCristiane Baccin Bendo Neves
dc.creatorJohn Pohl
dc.date.accessioned2024-05-13T18:22:32Z
dc.date.accessioned2025-09-09T01:28:28Z
dc.date.available2024-05-13T18:22:32Z
dc.date.issued2017-09
dc.identifier.doihttps://doi.org/10.1007/s11136-017-1702-6
dc.identifier.issn1573-2649
dc.identifier.urihttps://hdl.handle.net/1843/68233
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofQuality of Life Research
dc.rightsAcesso Restrito
dc.subjectColitis, ulcerative
dc.subjectCrohn disease
dc.subjectGastrointestinal diseases
dc.subjectIndicators of quality of life
dc.subjectInflammatory bowel diseases
dc.subjectLocal symptoms
dc.subjectMedication adherence
dc.subject.otherInflammatory bowel disease
dc.subject.otherCrohn’s disease
dc.subject.otherUlcerative colitis
dc.subject.otherGastrointestinal symptoms
dc.subject.otherMedication adherence barriers
dc.subject.otherPatient communication
dc.subject.otherPedsQL
dc.titlePerceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease
dc.typeArtigo de periódico
local.citation.epage204
local.citation.issue1
local.citation.spage195
local.citation.volume27
local.description.resumoObjectives: The primary objective was to investigate the mediating effects of patient-perceived medication adherence barriers in the relationship between gastrointestinal symptoms and generic health-related quality of life (HRQOL) in adolescents with inflammatory bowel disease (IBD). The secondary objective explored patient health communication and gastrointestinal worry as additional mediators with medication adherence barriers in a serial multiple mediator model. Methods: The Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms, Medicines, Communication, Gastrointestinal Worry, and Generic Core Scales were completed in a 9-site study by 172 adolescents with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, constipation, or diarrhea and perceived medication adherence barriers were tested for bivariate and multivariate linear associations with HRQOL. Mediational analyses were conducted to test the hypothesized mediating effects of perceived medication adherence barriers as an intervening variable between gastrointestinal symptoms and HRQOL. Results: The predictive effects of gastrointestinal symptoms on HRQOL were mediated in part by perceived medication adherence barriers. Patient health communication was a significant additional mediator. In predictive analytics models utilizing multiple regression analyses, demographic variables, gastrointestinal symptoms (stomach pain, constipation, or diarrhea), and perceived medication adherence barriers significantly accounted for 45, 38, and 29 percent of the variance in HRQOL (all Ps < 0.001), respectively, demonstrating large effect sizes. Conclusions: Perceived medication adherence barriers explain in part the effects of gastrointestinal symptoms on HRQOL in adolescents with IBD. Patient health communication to healthcare providers and significant others further explain the mechanism in the relationship between gastrointestinal symptoms, perceived medication adherence barriers, and HRQOL.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s11136-017-1702-6

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