Fatal viscerotropic and neurotropic disease after yellow fever vaccine: a rare manifestation leading to diagnosis of severe combined immunodeficiency in an infant

Página do item simplificado
dc.creatorLara Jhullian Tolentinovieira
dc.creatorLilian Martins Oliveira Diniz
dc.creatorGabriela Assunção Goebel
dc.creatorYuri Barcelos
dc.creatorLuciana Oliveira Cunha
dc.creatorLuisa Teles Melo Santos
dc.creatorRoberta Maia de Castro Romanelli
dc.creatorFernanda Gontijo Minafra
dc.creatorAndrea Lucchesi de Carvalho
dc.creatorLuiz Fernando Andrade de Carvalho
dc.date.accessioned2025-07-23T20:22:03Z
dc.date.accessioned2025-09-09T00:54:41Z
dc.date.available2025-07-23T20:22:03Z
dc.date.issued2024
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/S1678-9946202466050
dc.identifier.issn16789946
dc.identifier.urihttps://hdl.handle.net/1843/83786
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo
dc.rightsAcesso Aberto
dc.subjectYellow Fever
dc.subjectVaccine
dc.subject.otherVaccine.
dc.subject.otherImmunodeficiency
dc.subject.otherYellow Fever
dc.titleFatal viscerotropic and neurotropic disease after yellow fever vaccine: a rare manifestation leading to diagnosis of severe combined immunodeficiency in an infant
dc.typeArtigo de periódico
local.citation.epage5
local.citation.issuee50
local.citation.spage1
local.citation.volume66
local.description.resumoYellow fever vaccine (YFV) is a live attenuated vaccine that can cause a mild infection in immunocompetent patients. However, it may not be self-limiting in patients with inborn errors of immunity (IEI) and may be the first and most severe presentation in these patients. A 10-month-old female infant sought emergency care presenting fever for three days and diffuse exanthema. She was a previous healthy child of consanguineous parents. The child had received YFV 28 days before the onset of symptoms. Upon hospital admission, petechial rash on the limbs and hepatosplenomegaly were noted on physical exam. Laboratory tests showed thrombocytopenia, increased serum aminotransferases and elevated gamma-glutamyl transferase (GGT) and alkaline phosphatase levels. During hospitalization she developed hypoactivity, drowsiness, and hypotonia. The possibility of viscerotropic and neurotropic vaccine associated disease was suspected and a possible primary immunodeficiency disease considered. The patient was tested for antibodies against the yellow fever virus (MAC ELISA) on serum and cerebrospinal fluid (CSF) samples, showing positive IgM results. Immunophenotyping showed low levels of lymphocytes and absence of T-cell receptor excision circles (TREC), leading to diagnose of severe combined immunodeficiency disease (SCID). Despite treatment, after 35 days of hospitalization, she evolved to cardiorespiratory arrest and death. Serious adverse events after administration of the YFV are rare and associated with neurological or visceral involvement in most cases. The unfavorable outcome highlights the importance of neonatal screening for SCID and the clinical suspicion of primary immunodeficiencies in infants who have serious adverse events to live virus vaccines.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/rimtsp/a/hQhChbDC7sJPNvDMzqhxVZd/?lang=en

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Fatal viscerotropic and neurotropic disease after pdfa.pdf
Tamanho:
113.87 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG