Epidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018

Página do item simplificado
dc.creatorFilipe Romero Rebello Moreira
dc.creatorRodrigo Decembrino Vargas Brasil
dc.creatorDarlan da Silva Cândido
dc.creatorAlice Laschuk Herlinger
dc.creatorMarisa de Oliveira Ribeiro
dc.creatorMonica Barcellos Arruda
dc.creatorPatricia Alvarez
dc.creatorMarcelo Calado de Paula Tôrres
dc.creatorIlaria Dorigatti
dc.creatorOliver Brady
dc.creatorCarolina Moreira Voloch
dc.creatorMariane Talon de Menezes
dc.creatorRenato Santana de Aguiar
dc.creatorClarisse Salgado-benvindo
dc.creatorCharles Whittaker
dc.creatorVictoria Cox
dc.creatorNilani Chandradeva
dc.creatorHury Hellen Souza de Paula
dc.creatorAndré Frederico Martins
dc.creatorRaphael Rangel das Chagas
dc.date.accessioned2025-01-23T21:20:32Z
dc.date.accessioned2025-09-09T00:25:44Z
dc.date.available2025-01-23T21:20:32Z
dc.date.issued2023-09-28
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0011536
dc.identifier.issn1935-2735
dc.identifier.urihttps://hdl.handle.net/1843/79445
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofPLOS Neglected Tropical Diseases
dc.rightsAcesso Aberto
dc.subjectChikungunya
dc.subjectEpidemiologia
dc.subjectGénetica
dc.subjectBiologia
dc.subjectVírus
dc.titleEpidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018
dc.typeArtigo de periódico
local.citation.epage19
local.citation.issue9
local.citation.spage1
local.citation.volume17
local.description.resumoSince 2014, Brazil has experienced an unprecedented epidemic caused by chikungunya virus (CHIKV), with several waves of East-Central-South-African (ECSA) lineage transmission reported across the country. In 2018, Rio de Janeiro state, the third most populous state in Brazil, reported 41% of all chikungunya cases in the country. Here we use evolutionary and epidemiological analysis to estimate the timescale of CHIKV-ECSA-American lineage and its epidemiological patterns in Rio de Janeiro. We show that the CHIKV-ECSA outbreak in Rio de Janeiro derived from two distinct clades introduced from the Northeast region in mid-2015 (clade RJ1, n = 63/67 genomes from Rio de Janeiro) and mid-2017 (clade RJ2, n = 4/67). We detected evidence for positive selection in non-structural proteins linked with viral replication in the RJ1 clade (clade-defining: nsP4-A481D) and the RJ2 clade (nsP1-D531G). Finally, we estimate the CHIKV-ECSA’s basic reproduction number (R0) to be between 1.2 to 1.6 and show that its instantaneous reproduction number (Rt) displays a strong seasonal pattern with peaks in transmission coinciding with periods of high Aedes aegypti transmission potential. Our results highlight the need for continued genomic and epidemiological surveillance of CHIKV in Brazil, particularly during periods of high ecological suitability, and show that selective pressures underline the emergence and evolution of the large urban CHIKV-ECSA outbreak in Rio de Janeiro.
local.identifier.orcidhttps://orcid.org/0000-0002-7162-5070
local.identifier.orcidhttps://orcid.org/0000-0001-5180-3717
local.publisher.countryBrasil
local.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
local.publisher.initialsUFMG
local.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011536

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Epidemiological and genomic investigation of.pdf
Tamanho:
1.22 MB
Formato:
Adobe Portable Document Format
Baixar

Licença do pacote

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
License.txt
Tamanho:
1.99 KB
Formato:
Plain Text
Descrição:
Baixar

Coleções

Artigo de Periódico

Logo UFMG